Comparison of Different Neural Blockade Techniques in Postoperative Analgesia After Total Hip Arthroplasty

Not Applicable

• Conditions: Pain, Postoperative
• Interventions: Procedure: Fascia iliaca compartment block with IV-PCA; Procedure: Femoral nerve block and lateral femoral cutaneous nerve with IV-PCA; Procedure: IV-PCA

• Registration Number: NCT03231319
• Lead Sponsor: Taichung Veterans General Hospital

Brief Summary

To compare the different analgesic protocols for patients receiving total hip arthroplasty(THA). Patients will divided into 3 groups, which are 1. fascia iliaca compartment block with IV-PCA(patient controlled analgesia), 2. femoral nerve and lateral femoral cutaneous nerve block with IV-PCA, 3. IV-PCA only.

Detailed Description

90 patients will be enrolled and randomized to the 3 different groups.

1. Inclusion criteria:

Patient undergoing THA: 20-75 years old, ASA I-III, general anesthesia with intubation, fentanyl IV PCA.

2. Exclusion criteria Alcohol/substance abuse Rheumatoid arthritis Severe coagulation disorder(PLT\<80000 or INR \> 1.5) Peripheral neuropathy Allergy to opioids or local anesthetics BMI\>35

3. The outcome followers are blinded to the intervention provided.

4. Outcome parameters:

1. Opioid consumption of IV PCA in first 24 hrs.

2. NSAID consumption

3. NRS of pain, the timings of follow-up should be: pre-block, 30

mins post-block, 60 mins post-block, 2 hours post-block, 24hours post-block

4. sensory block in FN, Obturator Nerve and LFCN

5. First request of supplemental IV analgesia

Study Timeline

• Study First Submitted: 2017-06-22
• Status Verified: 2017-07
• Study First Submitted QC: 2017-07-25
• Last Update Submitted: 2017-07-25
• Study Start: 2017-07-27
• Study First Posted: 2017-07-27
• Last Update Posted: 2017-07-27
• Primary Completion: 2018-04-19
• Study Completion: 2018-04-19

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• ASA I-III, general anesthesia with intubation.
• fentanyl IV PCA

Exclusion Criteria

• Alcohol/substance abuse
• Rheumatoid arthritis
• Severe coagulation disorder(PLT<80000 or INR > 1.5)
• Peripheral neuropathy
• Allergy to opioids or local anesthetics
• BMI>35

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
fascia iliaca compartment block+ IV-PCA	Fascia iliaca compartment block with IV-PCA	-
femoral nerve and lateral femoral cutaneous nerve block+IV PCA	Femoral nerve block and lateral femoral cutaneous nerve with IV-PCA	-
IV PCA only	IV-PCA	-

Primary Outcome Measures

Name	Time	Method
Temporal changes of Pain score	1. Pre-intervention(which is the time when operation was done and the patient arrive postoperative care unit.) 2. 30 minutes after intervention, 3. 60 minutes after intervention, 4. 120 minutes after intervention, 5. 24 hours after intervention.	Pain score by numerical rating scale from pre-intervention to 24 hours after intervention(the effect of neural blockade seldom lasts more than 24 hours)

Secondary Outcome Measures

Name	Time	Method
NSAID consumptions	24 hours postoperatively
Opioid consumptions	postoperatively 24 hours	Including IV-PCA and other analgesics
Sensory block in femoral nerve, obturator nerve and lateral femoral cutaneous nerve area	1 hour post-intervention

Trial Locations

Locations (2)

Taichung Veterans General Hospital; 🇨🇳 Taichung, Taiwan

Dept. of Anesthesiology, Taichung Veterans General Hospital; 🇨🇳 Taichung, Taiwan