Effect of ketorolac and dexamethasone injections on pain after renal stent surgery
Phase 2
- Conditions
- Preventing renal colic post stent removalUrological and Genital Diseases
- Registration Number
- ISRCTN14221501
- Lead Sponsor
- Center for Fundamental Biomedical Clinical Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 174
Inclusion Criteria
1. Patients who underwent stent placement for renal/ureteral stones and returned for cystoscopical stent removal
2. Age between 20 and 85 years old
3. Providing informed consent
Exclusion Criteria
1. Absolute or relative contraindication to ketorolac or dexamethasone
2. Acute or chronic renal failure (estimated glomerular filtration rate <50)
3. History of GI bleeding or peptic ulcer disease
4. Elevated risk of bleeding including cerebrovascular bleeding, haemorrhagic diathesis, use of any anticoagulants, or any bleeding disorder
5. Systemic infections or cerebral malaria
6. Use of live or live-attenuated vaccines
6. Concurrent use of NSAIDs or corticosteroids
7. Pregnancy
8. Breastfeeding
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain measured using the visual analogue score (VAS) on day 1 and day 7
- Secondary Outcome Measures
Name Time Method 1. Opioid use, measured by the number of patients with any opioid use on day 1<br>2. Urgent pain-related clinical encounters, measured by the number of pain-related clinical encounters in the emergency department since the stent removal<br>3. Subjective renal colic symptoms, measured by the number of patients that experienced renal colic symptoms since the stent removal to day 7<br>4. Missed days of work, measured by the number of missed days of work since the stent removal to day 7<br>5. Injection complications, measured as the number of patients with any injection complication since the stent removal to day 7