NCT07581860尚未招募不适用
Growth Hormone Resistance of Beta-cells in People With Impaired Fasting Glucose vs Impaired Glucose Tolerance
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Beta-cell function
研究概览
简要总结
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with impaired fasting glucose or impaired glucose tolerance at the University of Missouri. The aim of the study is to advance understanding of how growth hormone affects beta-cells and risk factors for developing type 2 diabetes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 59 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •body mass index >18.5kg/m2 and <45.9kg/m2
- •impaired fasting glucose >/= 100mg/dL, </= 126mg/dL or impaired glucose tolerance on 75g oral glucose tolerance test (blood glucose 140 to 199mg/dL at two-hours)
排除标准
- •pregnant, planning to become pregnant during the study, or breastfeeding
- •current diagnosis or history of type 1 or type 2 diabetes
- •use of medications that can impact the study outcomes (e.g., GLP-1 receptor agonists)
- •history of bariatric surgery
- •known, uncontrolled hypothyroidism
- •history of intracranial hypertension, including papilledema, or a condition that increases the risk of developing intracranial hypertension, such as Turner Syndrome, Prader-Willi Syndrome, or renal impairment
- •current cancer or cancer that has been in remission less than 5 years
- •first degree relative with type 1 diabetes
- •evidence of anemia or significant end organ dysfunction (e.g., liver, kidney, heart disease)
- •alcohol use disorder, use of controlled substances, or smoking >2 cigarettes per day
- •greater than 3% weight loss within three months of screening or engaged in regular (>/= 3 days per week), continuous moderate- or high-intensity exercise of >/= 30 min duration
- •mentally disabled persons, prisoners, and persons with inability to grant voluntary informed consent
研究组 & 干预措施
Impaired fasting glucose
Impaired glucose tolerance
结局指标
主要结局
Beta-cell function
时间窗: before and 7 days after rhGH administration
Insulin secretion rate in relationship to plasma glucose
次要结局
未报告次要终点
研究者
Bettina Mittendorfer
Senior Associate Dean for Research; Professor, Medicine & Nutrition; NextGen Director of Clinical and Translational Sciences Unit
University of Missouri-Columbia
研究点 (1)
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