Prevention of Postoperative Atrial Fibrillation

Completed

• Conditions: Postoperative Atrial Fibrillation

• Registration Number: NCT01742039
• Lead Sponsor: George Washington University

Brief Summary

The primary aim of this study is to determine the safest and most effective therapeutic strategy to decrease the incidence of postoperative atrial fibrillation following cardiac surgery in an era with shorter ICU and hospital length of stay. A secondary goal is to evaluate the length of hospital stay associated with each treatment strategy.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-07
• Primary Completion: 2011-06
• Study Completion: 2011-06
• Study First Submitted: 2012-11-14
• Study First Submitted QC: 2012-12-03
• Study First Posted: 2012-12-05
• Status Verified: 2023-10
• Last Update Submitted: 2023-10-12
• Last Update Posted: 2023-10-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

• age > or = to 18 years
• sinus rhythm
• undergoing either coronary artery bypass graft surgery (CABG), valvular heart surgery or a combined procedure

Exclusion Criteria

• received a class-I or class-III antiarrhythmic agent in the past six months
• had second or third degree heart block
• had a resting heart rate of less than 50 beats per minute
• had a systolic blood pressure less than 100 mmHg
• had severe asthma or severe chronic obstructive pulmonary disease
• had uncontrolled heart failure
• had a serum aspartate aminotransferase or alanine aminotransferase concentration greater than four times the upper limit of normal

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
occurrence of atrial fibrillation	postoperative day 0-day of discharge (an average of 5 days)	The primary endpoint of this study was the occurrence of atrial fibrillation lasting longer than five minutes

Secondary Outcome Measures

Name	Time	Method
length of stay	participants will be followed for the duration of hospital stay, an expected average of 5 days	The secondary endpoint was the length of hospital stay after surgery.

Trial Locations

Locations (2)

George Washington University Hospital; 🇺🇸 Washington, District of Columbia, United States

George Washington University; 🇺🇸 Washington, District of Columbia, United States