Cognitive Enhancement Therapy for Adult Autism Spectrum Disorder
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 54
- 试验地点
- 2
- 主要终点
- Neurocognition
研究概览
简要总结
This study will investigate and contrast the effects of two psychological treatments for adults with autism spectrum disorder. Cognitive Enhancement Therapy (CET) is a cognitive remediation intervention that aims to help adults with problems in thinking, planning, and socialization. Enriched Supportive Therapy (EST) is an individual supportive therapy that aims to help adults learn about their condition, manage their emotions and stress, improve their social skills, and cope with everyday problems.
详细描述
Autism spectrum disorder (ASD) is characterized by marked impairments in social and non-social cognitive ability that persist well into adulthood and contribute to significant functional disability. The treatment of ASD has focused almost exclusively on children, and few empirically supported interventions are available to address the core cognitive and functional challenges individuals with ASD face as they transition to adulthood. This study will investigate and contrast the effects of two psychological treatments for adults with autism spectrum disorder. Cognitive Enhancement Therapy (CET) is a cognitive remediation intervention that aims to help adults with problems in thinking, planning, and socialization. Enriched Supportive Therapy (EST) is an individual supportive therapy that aims to help adults learn about their condition, manage their emotions and stress, improve their social skills, and cope with everyday problems.
Participation in this study will last 30 months. Potential participants must be able to attend weekly treatment sessions in Pittsburgh, PA.
The study design is a 30-month (2.5 years) randomized-controlled trial, where eligible participants will be randomized to the CET or EST study treatments. Participants will be treated with the study interventions for 18 months, and then followed for 12 additional months to assess the lasting impact of the study interventions. All participants will complete cognitive, clinical, and neuroimaging (magnetic resonance imaging) assessments prior to starting the study treatments and then at specified intervals thereafter to evaluate the impact of the study treatments on cognition, adaptive function, and the brain.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 16 Years 至 45 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 16-45 years
- •Diagnosis of autism, Asperger's syndrome, or pervasive developmental disorder not otherwise specified (NOS) verified by the autism diagnostic observation schedule (ADOS) or autism diagnostic interview-revised (ADI-R)
- •Presence of significant social and cognitive disability, based on the Cognitive Style and Social Cognition Eligibility Interview (Hogarty et al., 2004)
- •Intelligence quotient (IQ) greater than 80
- •Ability to read and speak fluent English
- •Availability of a family member or close friend allowed to provide information on the participant
- •Ability to attend weekly treatment sessions in Pittsburgh, PA
排除标准
- •Organic brain syndrome
- •English language skills below a sixth grade level
- •Persistent suicidal or homicidal behavior
- •History of substance abuse or dependence within the past 3 months
- •Comorbid attention deficit hyperactivity disorder (ADHD)
- •Comorbid personality disorder
- •History of disruptive or violent behavior
- •Any magnetic resonance imaging contraindications
结局指标
主要结局
Neurocognition
时间窗: Pre-treatment, 9, 18, and 30 months
Composite measure of neuropsychological tests designed to assess neurocognitive function
Social cognition
时间窗: Pre-treatment, 9, 18, and 30 months
Composite measure of performance-based and interview tests designed to assess social-cognitive function
次要结局
- Functional outcome(Pre-treatment, 9, 18, and 30 months)
研究者
Shaun M. Eack
Professor of Social Work and Psychiatry
University of Pittsburgh