Exercise Therapy for Patients Awaiting Allogeneic Hematological Stem Cell Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Change in Physical Function
研究概览
简要总结
The investigators hypothesize that inactivity during the search for a donor may exacerbate current deconditioned states; subsequently, influencing risk factors for post-transplant complications that hinder the recovery phase.
This study is designed to investigate if exercise therapy administered prior to allogeneic hematologic stem cell transplantation (HSCT) can influence physical and psychological side-effects associated with HSCT. Approximately 6-weeks prior to HSCT, individuals will be randomized into either an exercise group or usual care group and followed until one year after HSCT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 17 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Medical indication: allogeneic stem cell transplantation at Princess Margaret Hospital
- •must be ambulatory without need for human assistance at time of recruitment
- •medically cleared to exercise by the transplant physician
- •demonstrates willingness to attend supervised sessions
- •sufficient in English to ensure safety of understanding prescribed exercise guidelines, or has access to an adequate non-familial interpreter
排除标准
- •another active malignancy
- •less than 4 weeks till the scheduled HSCT
- •refusal to be randomized
- •does not have the approval of their transplant physician
- •severe or unstable neurological, cardiorespiratory, musculoskeletal disease or mental illness
研究组 & 干预措施
Exercise
Individuals will participate in weekly supervised and unsupervised exercise sessions prior to HSCT, during hospitalization and till 100 days from HSCT. Exercise will consist of endurance and resistance exercise 3-5 days a week.
干预措施: Exercise (Behavioral)
Usual Care
Usual care will have continue with standard of care treatment without any specific exercise instruction or guidance other than what is provided by the patient education team at the cancer centre.
结局指标
主要结局
Change in Physical Function
时间窗: Baseline, 1 week pre HSCT, T100, 1yr post HSCT
Cardiopulmonary Capacity (VO2peak)
次要结局
- Change in Anxiety(Baseline, 1 week pre HSCT, T100, 1yr post HSCT)
- Change in Symptoms(Baseline, 1 week pre HSCT, T100, 1yr post HSCT)
- Change in Treatment Side-effects(Baseline, 1 week pre HSCT, T100, 1yr post HSCT)
- Change in Six-minute walk test(Baseline, 1 week pre HSCT, T100, 1yr post HSCT)
- Change in Quality of Life(Baseline, 1 week pre HSCT, T100, 1yr post HSCT)
- Change in Depression(Baseline, 1 week pre HSCT, T100, 1yr post HSCT)
- Change in Fatigue(Baseline, 1 week pre HSCT, T100, 1yr post HSCT)
- Change in Strength(Baseline, 1 week pre HSCT, T100, 1yr post HSCT)