NCT04379193已完成不适用
Ambulatory Neuroproprioceptive Facilitation and Inhibition Physical Therapy Does Not Modulate Serum Level of Neuroactive Steroids
Charles University, Czech Republic0 个研究点目标入组 63 人开始时间: 2015年5月20日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 63
- 主要终点
- serum level of neuroactive steroids
研究概览
简要总结
This study describes modulation of neuroproprioceptive facilitation and inhibition physical therapy on serum level of neuroactive steroids in multiple sclerosis.
详细描述
In the parallel group, single blind, randomized controlled trial, participant underwent two kinds of neuroproprioceptive PT (MPAT and VRL). At baseline and after the end of the two months' therapeutic program, a blinded assessor evaluated clinical outcomes and data from serum level.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •prevailed spastic paraparesis, stable clinical status and treatment in the preceding 3 months determined by neurologist,
- •Expanded Disability Status Scale score (EDSS) max. 7.5
排除标准
- •other neurological disease or conditions disabling movement
结局指标
主要结局
serum level of neuroactive steroids
时间窗: 2 months
cortisol, cortisone, 7 alfa-OH-DHEA, 7 beta-OH-DHEA, 7 oxo- oxo-DHEA, DHEA
次要结局
- Berg Balance Scale, BBS outcomes(2 months)
- Paced Auditory Serial Addition Test(2 months)
- the 29-item Multiple Sclerosis Impact Scale, MSIS -29(2 months)
- Modified Fatigue Impact Scale(2 months)
研究者
Kamila Řasová
assoc. prof. Kamila Řasová, Ph.D.
Charles University, Czech Republic
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