NCT04379193
Completed
Not Applicable
Ambulatory Neuroproprioceptive Facilitation and Inhibition Physical Therapy Does Not Modulate Serum Level of Neuroactive Steroids
Charles University, Czech Republic0 sites63 target enrollmentMay 20, 2015
ConditionsMultiple Sclerosis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- Charles University, Czech Republic
- Enrollment
- 63
- Primary Endpoint
- serum level of neuroactive steroids
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
This study describes modulation of neuroproprioceptive facilitation and inhibition physical therapy on serum level of neuroactive steroids in multiple sclerosis.
Detailed Description
In the parallel group, single blind, randomized controlled trial, participant underwent two kinds of neuroproprioceptive PT (MPAT and VRL). At baseline and after the end of the two months' therapeutic program, a blinded assessor evaluated clinical outcomes and data from serum level.
Investigators
Kamila Řasová
assoc. prof. Kamila Řasová, Ph.D.
Charles University, Czech Republic
Eligibility Criteria
Inclusion Criteria
- •prevailed spastic paraparesis, stable clinical status and treatment in the preceding 3 months determined by neurologist,
- •Expanded Disability Status Scale score (EDSS) max. 7.5
Exclusion Criteria
- •other neurological disease or conditions disabling movement
Outcomes
Primary Outcomes
serum level of neuroactive steroids
Time Frame: 2 months
cortisol, cortisone, 7 alfa-OH-DHEA, 7 beta-OH-DHEA, 7 oxo- oxo-DHEA, DHEA
Secondary Outcomes
- Berg Balance Scale, BBS outcomes(2 months)
- Paced Auditory Serial Addition Test(2 months)
- the 29-item Multiple Sclerosis Impact Scale, MSIS -29(2 months)
- Modified Fatigue Impact Scale(2 months)
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