Validation of New Tools for the Assessment of Cognitive Functions and Connectivity Network in Hypertensive Patients

Completed

• Conditions: Cognitive Impairment; Hypertension

• Registration Number: NCT02310217
• Lead Sponsor: Neuromed IRCCS

Brief Summary

The relationship among hypertension, aging and cognitive decline is complex and not completely understood. Purpose of this project will be evaluating early markers of cognitive deterioration in patients with arterial hypertension. In particular, this cross-sectional observational study will be articulated in three phases:

1. Neuropsychological evaluation of general cognitive abilities

2. Identification and measurement of specific biomarker levels

3. Correlation among hypertension, cognitive abilities and biomarkers.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-11-28
• Study First Submitted QC: 2014-12-05
• Study First Posted: 2014-12-08
• Study Start: 2015-02
• Primary Completion: 2020-12
• Study Completion: 2020-12
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-19
• Last Update Posted: 2022-04-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

• Males or females diagnosed with arterial hypertension between 40 and 65 years of age;
• Written informed consent prior to enrollment in the study.

Exclusion Criteria

• Precedent acute myocardial infarction (AMI);
• Previous stroke and/or transient ischemic attack (TIA);
• Previous or concomitant neurologic or psychiatric pathologies;
• Neurologic or psychiatric pharmacological therapy.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cognitive abilities measured by validated neuropsychological test battery (Montreal Cognitive Assessment test, Verbal Fluency test,learning of couple words, Stroop test)	18 months

Trial Locations

Locations (1)

IRCCS Neuromed; 🇮🇹 Pozzilli, (is), Italy