IMAGINE-Study (Imaging in Epilepsy)Onderzoek naar de oorzaak van geheugenproblemen en falen van medicamenteuze behandeling bij kinderen met frontaalkwab epilepsie.
Recruiting
- Registration Number
- NL-OMON28826
- Lead Sponsor
- Epilepsy Center Kempenhaeghe
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria
Inclusion criteria for children with FLE:
1. Age of 8 to12 years;
Exclusion Criteria
Exclusion criteria for children with FLE:
1. Multiple seizure foci involving more than one lobe of the brain documented on previous EEG studies;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Macrostructural, microstructural and functional MRI parameters, combined with seizure history, IQ, and response to anti-epileptic drug treatment. The endpoints for the fMRI tasks are activation levels of different brain areas and the correlation between the time signals between these activated brain areas. This will be analysed pixel by pixel with an automatized computer analysis (SPM software). Herewith, we obtain a list of activation levels and correlation coefficients for every brain region for every patient and every healthy control. Hereafter, these data can, for every task, be statistically compared between patients and healthy controls. This is a standardized and well applied way of data analysis. Endpoints therefore include the activated brain regions and the level of interaction between these regions. This will be processed in terms of: <br /><br>1. Correlation between fMRI results and neuropsychological test results, and;<br /><br>2. Differences between patients and healthy controls.
- Secondary Outcome Measures
Name Time Method Patient characteristics and epilepsy-related factors which may be responsible for cognitive impairment and refractoriness.