Assessment of excretion kinetics of urinary biomarkers after a single oral dose of zearalenone in healthy adults
- Conditions
- toxicologystudy of the adverse effects of chemical substances on living organisms
- Registration Number
- NL-OMON49818
- Lead Sponsor
- Wageningen Food Safety Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 24
* Healthy subjects (self-reported), aged 18-65 years.
* Subjects with a BMI of 18.5 kg/m2 and below, or 30 kg/m2 and above.
* Subjects using prescribed medication during the duration of the study.
* Pregnant women or women intending to become pregnant during the duration of
the study.
* Breastfeeding women.
* Women menstruating at the anticipated days of sample collection.
* Intestinal, liver, biliary, or kidney disease, ileostomy, chronic diarrhea,
chronic constipation, celiac disease
* Occupation: working in or frequently visiting (>2d/week) grain silos or flour
factories.
* Working at WFSR.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>concentrations of ZEN biomarkers (ZEN, *-ZEL, and *-ZEL, measured after<br /><br>enzymatic deconjugation) excreted in urine over ~72h after ingestion of a<br /><br>single dose of ZEN.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable.</p><br>
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