To Explore the Effect of Probiotic Supplements in Chronic Kidney Disease
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 80
- Locations
- 2
- Primary Endpoint
- Blood Urea Nitrogen (BUN) levels
Study Overview
Brief Summary
This research will investigate the effect of oral probiotic supplements on renal function, uremic toxins inflammatory response, nutrition status, gastrointestinal symptoms, and QoL with Chronic kidney disease.
Detailed Description
Chronic kidney disease (CKD) with gut microbiota was different from a normal person. Some gut microbiota produces short-chain fatty acids or induces functional enzymes beneficial to patients. On the other hand, some gut microbiota may also metabolize amino acids into p-cresol and indole which were leading to the accumulation of urinary toxins and damage to the kidney. This research will investigate the effect of oral probiotic supplements on renal function, uremic toxins, inflammatory response, nutrition status, gastrointestinal symptoms, and QoL with CKD.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Other
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 20 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Blood Urea Nitrogen (BUN) levels
Time Frame: Baseline to 24 week
Blood Urea Nitrogen
Estimated glomerular filtration rate (eGFR) measurement
Time Frame: Baseline to 24 week
The eGFR level is a maker for kidney function
Electrolytes Analysis
Time Frame: Baseline to 24 week
The concentration of electrolytes analysis in the subject's blood samples
Secondary Outcomes
- Lipid analysis(Baseline to 24 week)
- 24-hour Dietary recall(Baseline to 24 week)
- The quality of life(Baseline to 24 week)
- Complete Blood Count (CBC) Test(Baseline to 24 week)
- Uremic toxins assay(Baseline to 24 week)
- Sugar test(Baseline to 24 week)
- Inflammation makers(Baseline to 24 week)
- Urine Analysis(Baseline to 24 week)
- Safety and compliance(Baseline to 24 week)
- Grip strength levels(Baseline to 24 week)
- Nutrition status(Baseline to 24 week)
- Liver function(Baseline to 24 week)