The Mechanism Underlying Different Incidence of Post Stroke Depression in Patients with Distinct Chinese Medicine Syndromes of Acute Ischemic Sroke Based on Inflammatory Factors and Gut Microbiota of Brain-Gut Axis

Not Applicable

Recruiting

• Conditions: post-stroke depression

• Registration Number: ITMCTR2100004659
• Lead Sponsor: Xuanwu Hospital Capital Medical University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1.Aged 45-70 years;
2.Meeting the diagnostic criterion for cerebral infarction within 72 hours of onset;
3.Meeting the diagnostic criterion of cerebral infarction for Tan Re Fu Shi or Qi Xu Xue Yu in Traditional Chinese Medicine;
4.HAMD < 8;
5.NIHSS 0-15;
6.mRS 0-2;
7.Conscious, expressing clearly and able to cooperate with clinicians in the collection of clinical information;
8.Linving in Beijing;
9.Informed consent.
Patients who meet the criterion above simultaneously can be recruited.

Exclusion Criteria

1.WIth a history of depression;
2.With unstable vital signs;
3.Cerebral hemorrhage or mixed stroke;
4.Temporal lobe infarction lesions and with severe aphasia, agnosia, hearing or vision impairment, aphasia or dyslexic speech and cognitive impairment;
5.With serious diseases;
6.Alcoholism or substance dependence;
7.With (a history of) other psychosis or nervous system diseases resulting in impaired cognition;
8.Refusing or unable to cooperating;
9.Pregnancy;
10.With any surgery, medication, food or something that affecting gut microbiota;
Patients who meet anyone of criterion above should be excluded.

Study & Design

• Study Type: Observational study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
gut microbiota;Depression-related metabolites;Inflammatory Factors;