Effect of Transcranial Direct Current Stimulation (tDCS) on Appetite Control Related Brain Regions

Not Applicable

Completed

• Conditions: Obesity
• Interventions: Device: tDCS

• Registration Number: NCT02362542
• Lead Sponsor: Chungbuk National University

Brief Summary

The purpose of this study is to investigate the effect of Transcranial Direct Current Stimulation (tDCS) on appetite control related brain regions.

Detailed Description

Transcranial direct current stimulation (tDCS) is emerging tool for brain modulation in a variety of clinical conditions. In addition, recent neuroimaging studies suggest that modifying the activity of brain circuits involved in eating behavior could provide therapeutic benefits in obesity.

The investigators aim to assess whether modulation of the dorsolateral prefrontal cortex (DLFPC) using tDCS, modifies behavioral response and brain activity while watching visually presented food cues in obese subjects.

Subjects will receive tDCS two times, one is active stimulation and the other is sham stimulation. Both stimulations will be separated at least one week and the order of sham and active tDCS will be counterbalanced across subjects.

Subjects will perform functional MRI experiments with visual food cues. Questionnaire with behavior measures, body compositions, blood tests will be performed.

Study Timeline

• Study Start: 2015-02
• Study First Submitted: 2015-02-02
• Study First Submitted QC: 2015-02-09
• Study First Posted: 2015-02-13
• Primary Completion: 2015-10
• Status Verified: 2016-02
• Last Update Submitted: 2016-02-03
• Last Update Posted: 2016-02-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• BMI > 28 kg/m2

Exclusion Criteria

• history of brain trauma, epilepsy, or other neurological problems

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Real tDCS	tDCS	Subjects will receive tDCS two times, one is active stimulation and the other is sham stimulation. Both stimulations will be separated at least one week and the order of sham and active tDCS will be counterbalanced across subjects.
Sham tDCS	tDCS	Subjects will receive tDCS two times, one is active stimulation and the other is sham stimulation. Both stimulations will be separated at least one week and the order of sham and active tDCS will be counterbalanced across subjects.

Primary Outcome Measures

Name	Time	Method
Regional brain activity measured by blood-oxygen-level dependent (BOLD) signal of functional MRI	Immediately after intervention	3T MR scanner with Echo Planar Imaging(EPI) capability(Magnetom, Siemens Medical System)

Secondary Outcome Measures

Name	Time	Method
Behavior outcomes on the visual analog scale	Immediately after intervention	Hunger related visual analogue scale (VAS) - 8 items (Flint et al., 2000) Mood related visual analogue scale (VAS) - 16 items (Fregni et al., 2008)

Trial Locations

Locations (1)

Chungbuk National University; 🇰🇷 Cheongju, Chungcheongbuk-Do, Korea, Republic of