Rapid Eye Movement Restoration and Enhancement for Sleep-deprived Trauma-adaptation
- Conditions
- Healthy Volunteers
- Registration Number
- NCT06547086
- Lead Sponsor
- University of Wisconsin, Madison
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria:<br><br> - Adults aged 18-50 years<br><br> - Medically healthy<br><br> - English-speaking (able to provide consent and complete questionnaires)<br><br> - Citizen or holding permanent resident status<br><br> - Regular napper (1 or more naps per week)<br><br>Exclusion Criteria:<br><br> - Any current or past history of neurological disorders or acquired neurological<br> disease (e.g. stroke, traumatic brain injury), including intracranial lesions<br><br> - History or head trauma resulting in prolonged loss of consciousness; or a history of<br> >3 grade 1 concussions<br><br> - Current history of poorly controlled headaches including intractable or poorly<br> controlled migraines<br><br> - Any systemic illness or unstable medical condition that may cause a medical<br> emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia,<br> asthma, etc)<br><br> - History of seizures, diagnosis of epilepsy, histoy of abnormal (epileptiform) EEG,<br> or family history of treatment resistant epilepsy with the exception of a single<br> seizure of benign etiology (e.g. febrile seizures) in the judgment of a<br> board-certified neurologist<br><br> - Possible pregnancy or plan to become pregnant in the next 6 months<br><br> - Any metal in the body<br><br> - Any medical devices or implants (i.e. cardiac pacemaker, medication infusion pump,<br> cochlear implant, vagal nerve stimulator) unless otherwise approved by the<br> responsible MD<br><br> - Dental implants containing metal<br><br> - Any medication that may alter seizure threshold: ADHD stimulants (Adderall,<br> amphetamine); tricyclic/stypical antidepressants (amitriptyline, doxepine,<br> imipramine, maprotiline, nortriptyline, buproprion); antipsychotics (chlorpromazine,<br> clozapine); bronchodilators (theophylline, aminophylline); antibiotics<br> (fluoroquinolones, imipenem, penicillin, cephalosporins, metronidazole, isoniazid);<br> Antivirals (valacyclovir, ritonavir); OTC antihistamines (diphenhydramine, Benadryl)<br><br> - Claustrophobia (a fear of small or closed places)<br><br> - Back problems that would prevent lying flat for up to two hours<br><br> - Regular night-shift work (second or third shift)
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Identify effective TES-TI parameters to trigger spindles;Identify effective TES-TI parameters to trigger spindles;Identify effective duration of the nap to maximize TES-TI effect on REM sleep;Change in spindles after effective TES-TI intervention;Change in sawtooth waves after effective TES-TI intervention;Change in score for vigilance task;Change in sleep quality and mood;Change in sleepiness;Change in emotion response;Change in Spectral Power in Sawtooth Wave Frequency (3-5Hz);Change in minutes scored as REM sleep
- Secondary Outcome Measures
Name Time Method