Repetitive Transcranial Magnetic Stimulation for Freezing of Gait
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- The number of steps
研究概览
简要总结
Freezing of gait (FOG) means that patients cannot walk without any known causes, other than parkinsonism, which is very disabling symptom. Patients descirbe their feeling of the feet suddenly being glued to the floor. Transcranial magnetic stiumation is a noninvasive procedure using electromagnetic induction to stimulate brain. Transcranial magnetic stiumation (rTMS) can selectively change brain activity to enhance desired effects. The aim of this study is to the therapeutic effect of rTMS for the FOG.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Parkinson's disease or Primary progressive freezing of gait
- •age 18 and older
- •Freezing of gait
排除标准
- •pregnant or any, other medical, surgical, neurological or psychiatric conditions
- •other restrictions which prevent you from undergoing TMS recording, such as; surgically or traumatically implanted foreign bodies such as a pacemaker, an implanted medication pump, a metal plate in the skull, or metal inside the skull or eyes (other than dental appliances or fillings), and/ or heart/cardiac lines
- •any past or current history of seizure disorder or epilepsy
- •unable to give informed consent
研究组 & 干预措施
rTMS Motor cortex
rTMS will be applied over the motor cortex
干预措施: rTMS Motor cortex (Device)
rTMS Supplementary motor area
rTMS will be applied over the supplementary motor area
干预措施: rTMS Supplementary motor area (Device)
结局指标
主要结局
The number of steps
时间窗: 2 days
The number of steps during the stand-walk-sit (SWS) test
次要结局
- Freezing episodes of gait trajectory(2 days)
- Patient and Clinical Global Impression Scale(2 days)
- The completion time during the SWS test(2 days)
研究者
Suk Yun Kang
MD, PhD
Dongtan Sacred Heart Hospital