Repetitive Transcranial Magnetic Stimulation for Freezing of Gait

Not Applicable

Completed

• Conditions: Parkinsonian Disorders
• Interventions: Device: rTMS Supplementary motor area; Device: rTMS Motor cortex

• Registration Number: NCT01853150
• Lead Sponsor: Dongtan Sacred Heart Hospital

Brief Summary

Freezing of gait (FOG) means that patients cannot walk without any known causes, other than parkinsonism, which is very disabling symptom. Patients descirbe their feeling of the feet suddenly being glued to the floor. Transcranial magnetic stiumation is a noninvasive procedure using electromagnetic induction to stimulate brain. Transcranial magnetic stiumation (rTMS) can selectively change brain activity to enhance desired effects. The aim of this study is to the therapeutic effect of rTMS for the FOG.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-04
• Study First Submitted: 2013-05-10
• Study First Submitted QC: 2013-05-10
• Study First Posted: 2013-05-14
• Status Verified: 2018-07
• Primary Completion: 2018-07
• Study Completion: 2018-07
• Last Update Submitted: 2018-07-23
• Last Update Posted: 2018-07-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Parkinson's disease or Primary progressive freezing of gait
• age 18 and older
• Freezing of gait

Exclusion Criteria

• pregnant or any, other medical, surgical, neurological or psychiatric conditions
• other restrictions which prevent you from undergoing TMS recording, such as; surgically or traumatically implanted foreign bodies such as a pacemaker, an implanted medication pump, a metal plate in the skull, or metal inside the skull or eyes (other than dental appliances or fillings), and/ or heart/cardiac lines
• any past or current history of seizure disorder or epilepsy
• unable to give informed consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
rTMS Supplementary motor area	rTMS Supplementary motor area	rTMS will be applied over the supplementary motor area
rTMS Motor cortex	rTMS Motor cortex	rTMS will be applied over the motor cortex

Primary Outcome Measures

Name	Time	Method
The number of steps	2 days	The number of steps during the stand-walk-sit (SWS) test

Secondary Outcome Measures

Name	Time	Method
Freezing episodes of gait trajectory	2 days
Patient and Clinical Global Impression Scale	2 days
The completion time during the SWS test	2 days

Trial Locations

Locations (1)

Dongtan Sacred Heart Hospital; 🇰🇷 Hwaseong Si, Gyeonggi-Do, Korea, Republic of