Neural and Mobile Assessment OF Behavior Change Among Problem Drinkers
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Alcohol Use Disorder
- Sponsor
- New York State Psychiatric Institute
- Enrollment
- 164
- Locations
- 1
- Primary Endpoint
- Drinking
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
This study will examine the neural mechanisms underlying both spontaneous behavior change and behavior change in response to a brief intervention among problem drinkers.
Detailed Description
Although problem drinkers (PD) are a less severe, highly prevalent sub-type of alcohol use disorder (AUD) who are more likely to undergo reductions in alcohol use, compared to more severe AUD, the underlying mechanisms that maintain PD, as well as the mechanisms that underlie both spontaneous and treatment- related behavior change in this population, are not well understood. This proposal takes a lab to life approach by combining functional neuroimaging (fMRI), ecological momentary assessment (EMA), and brief interventions (BI) in non-treatment seeking PD to test whether heightened incentive salience (reactivity) to alcohol cues and impaired ability to regulate cue-induce craving are the mechanisms that characterize PD, and play a role in behavior change vs. persistence of behavior. Identifying these mechanisms is critical for testing and understanding treatments and uncovering who is most likely to respond to interventions.
Investigators
Nasir Naqvi
research psychiatrist
New York State Psychiatric Institute
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •Past or current severe AUD as defined by DSM- V
- •Currently seeking treatment or attempting to stop drinking
- •Past or current alcohol withdrawal symptoms
- •Current DSM-V diagnosis of substance use disorder (other than nicotine or caffeine).
- •Regular use (more than 1-2 times weekly) of recreational drugs.
- •Psychotic Disorder or Bipolar disorder
- •Severe depression (Patient Health Questionnaire score \> 19) or anxiety (Beck Anxiety Inventory \> 25)
- •Substantial risk of suicide or violence
- •MRI contraindications (e.g., metallic implants, pacemaker, weight \> 350 lbs, waist \> 55")
- •Hearing impaired/hearing aids, unable to read newspaper at arm's length with corrective
Outcomes
Primary Outcomes
Drinking
Time Frame: 6 months
Heavy drinking days