Cognitive behavioural therapy for People with Asperger Syndrome and Anxiety disorders

Completed

• Conditions: Topic: Mental Health Research Network, Primary Care Research Network for England; Subtopic: Anxiety, Autism spectrum disorders, Not Assigned; Disease: Anxiety, Autism spectrum disorders; Mental and Behavioural Disorders; Asperger's syndrome

• Registration Number: ISRCTN30265294
• Lead Sponsor: orfolk and Waveney Mental Health NHS FT (UK)

Brief Summary

2013 protocol in http://www.ncbi.nlm.nih.gov/pubmed/23901031 2016 results in: http://www.ncbi.nlm.nih.gov/pubmed/27703772

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-02-20
• Study Completion: 2012-08-08
• Last Update Posted: 14 January 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

1. Participants must fulfill diagnostic criteria for AS, or high functioning autism (Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS)), and have been diagnosed with AS or PDD-NOS by a paediatrican, clinical psychologist or psychiatrist. The features of AS and PDD-NOS include difficulties with social interaction marked by problems with nonverbal behaviour, and peer relationships. They also have problems with social reciprocity, coupled with stereotyped patterns of behaviour and interests that may be repetitive, as well as clinically significant difficulties with occupational and social functioning. People with AS generally do not have language developmental delays or intellectual disabilities. Only participants with a current diagnosis of AS or PDDNOS will be considered for inclusion within the trial. We will make use of the Krug Asperger Disorder Index as an aide to confirming diagnosis.
2. Participants must have clinical significant difficulties with anxiety and fulfill diagnostic criteria for one or more of the following disorders: panic disorder, agoraphobia, social phobia (social anxiety disorder), specific phobias, or generalised anxiety disorder. This will be confirmed through the use of our screening instruments, such as the Hamilton Rating Scale for Anxiety, and an assessment and screening interview.
3. Participants must be aged 16 or over.; Target Gender: Male & Female; Upper Age Limit 65 years ; Lower Age Limit 16 years

Exclusion Criteria

1. If suffering from post-traumatic stress disorder, or anxiety related to substance misuse. The reason for this exclusion is that people suffering from these disorders may require more specialist intervention as a consequence of the aetiology of these disorders (e.g. trauma and addiction)
2. They have other types of severe mental illness such as psychosis
3. They are currently abusing substances such as alcohol or heroin
4. They have an intellectual disability

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. Social Phobia Inventory (Connor et al., 2000)<br> 2. Liebowitz Social Anxiety Scale (Heimberg et al.)<br> Timepoint(s): Administered on Three Occassions<br><br> Measured before the intervention starts, after the intervention is finished, and at six months after the intervention has finished<br>

Secondary Outcome Measures

Name	Time	Method
<br> 1. Resource Use Questionnaire; Timepoint(s): Administered on Three Occassions<br> 2. SF-36 (www.sf-36.org) and EQ-5D (www.euroqol.org) generic health-related quality of life scales.; Timepoint(s): Administered on Three Occassions<br> 3. Social and Emotional Functioning Interview (Informant and Subject Versions; Rutter et al., 1988); Timepoint(s): Administered on Three Occassions<br> 4. Social Interaction Anxiety Scale (Heimberg et al., 1992; Brown et al., 1997), and<br> 5. Fear Questionnaire; Timepoint(s): Administered on Three Occassions<br><br> Measured before the intervention starts, after the intervention is finished, and at six months after the intervention has finished<br>