NCT04417348已完成不适用
Expression of Opsins Receptors in Melasma and Its Modification With UV-Visible Light Sunscreen and 0.05% Retinoic Acid.
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- MASI score
研究概览
简要总结
Melasma is a hyperpigmentation disorder that is probably exacerbated by visible light. Opsin receptors (OPN 1, 2, 3, 4 y 5) were described in the skin, being capable of activating melanogenesis induced by visible light. The aim of this study was to evaluate the expression of OPN in melasma skin and its changes following treatment with UV-Vis filter and 0.05% retinoic acid for 12 weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Patients diagnosed with melasma, of 18 years of age and older, without previous treatment or photoprotection measures within the previous 4 weeks, who had Melasma Activity and Severity Index (MASI) scores higher than 7
排除标准
- •pregnancy or nursing, menopause, coexistence of other pigmentation conditions, heat exposure, regular exercise, diet restriction, consumption of food supplements or any type of drugs (including anti-inflammatories and hormonal treatments) within the previous 2 months, and women who had given birth within 1 year
研究组 & 干预措施
Retinoic Acid
Active Comparator
patients with melasma treated with 0.05% retinoic acid plus UV-Visible light filter
干预措施: Retinoic acid (Drug)
Sunscreen
Placebo Comparator
patients with melasma treated with UV-Visible light filter alone
干预措施: Retinoic acid (Drug)
结局指标
主要结局
MASI score
时间窗: 3 months
Melasma Activity and Severity Index
次要结局
- Opsin receptors(3 months)
研究者
Juan Pablo Castanedo-Cazares
Adjunt professor
Universidad Autonoma de San Luis Potosí
研究点 (1)
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