Expression of Opsins Receptors in Melasma and Its Modification With UV-Visible Light Sunscreen and 0.05% Retinoic Acid.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 15
- Locations
- 1
- Primary Endpoint
- MASI score
Study Overview
Brief Summary
Melasma is a hyperpigmentation disorder that is probably exacerbated by visible light. Opsin receptors (OPN 1, 2, 3, 4 y 5) were described in the skin, being capable of activating melanogenesis induced by visible light. The aim of this study was to evaluate the expression of OPN in melasma skin and its changes following treatment with UV-Vis filter and 0.05% retinoic acid for 12 weeks.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 60 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Patients diagnosed with melasma, of 18 years of age and older, without previous treatment or photoprotection measures within the previous 4 weeks, who had Melasma Activity and Severity Index (MASI) scores higher than 7
Exclusion Criteria
- •pregnancy or nursing, menopause, coexistence of other pigmentation conditions, heat exposure, regular exercise, diet restriction, consumption of food supplements or any type of drugs (including anti-inflammatories and hormonal treatments) within the previous 2 months, and women who had given birth within 1 year
Arms & Interventions
Retinoic Acid
patients with melasma treated with 0.05% retinoic acid plus UV-Visible light filter
Intervention: Retinoic acid (Drug)
Sunscreen
patients with melasma treated with UV-Visible light filter alone
Intervention: Retinoic acid (Drug)
Outcomes
Primary Outcomes
MASI score
Time Frame: 3 months
Melasma Activity and Severity Index
Secondary Outcomes
- Opsin receptors(3 months)
Investigators
Juan Pablo Castanedo-Cazares
Adjunt professor
Universidad Autonoma de San Luis Potosí