Systemic Inflammatory Response Syndrome (SIRS) in Patients Undergoing Major Procedures in Oral and Maxillofacial Surgery
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS)
- Registration Number
- NCT01921049
- Lead Sponsor
- University of Cologne
- Brief Summary
Patients undergoing major procedures in oral and maxillofacial surgery more often develop a systemic inflammatory response syndrome (SIRS) in the first days of postoperative critical care therapy than patients with a comparable major surgery in other regions. The reasons for this finding are unknown and have not been studied in depth so far. We hypothesize that surgical trauma in this region might activate pro-inflammatory pathways. By examining the proteome of patients at different stages (prior to the surgery, at ICU admission, on the second postoperative day and when SIRS has ended clinically), we aim to identify the involved pro-inflammatory pathways and identify possible target proteins that might be clues to modification of postoperative SIRS in the future.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 27
- age 18-99yrs
- scheduled for elective surgery with risk for development of SIRS
- written and informed consent
- age <18yrs
- pregnancy
- emergency surgery
- failure to obtain patient consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method change of concentration of pro-inflammatory cytokines [µg/l] up to 10 days post surgery Change of concentration of pro-inflammatory cytokines from pre-operative sample over icu-admission, 2nd postoperative day and clinical end of SIRS.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Anaesthesiology and Critical Care Medicine, University Hospital of Cologne
🇩🇪Cologne, Germany