Innovative improving method of Osteoarthritis (OA) using autologous adipose-derived stromal vascular fraction (SVF) cells

Not Applicable

Conditions: Diseases of the musculoskeletal system and connective tissue

Registration Number: KCT0006220

Lead Sponsor: Thecellchaewon hospital

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot yet recruiting

Sex: All

Target Recruitment: 50

Inclusion Criteria

1. Males or females 30~65 years old who have not been improved and continuously reoccurred despite of medication or physical treatments after diagnosing the disease related to joint.
2. Grade II or Grade III osteoarthritis using Kellgren-Lawrence grading scale (K-L Grade)
3. BMI =22 and = 37

Exclusion Criteria

1. Subjects that have had a history of bleeding control disorder or can’t stop using anti-inflammatory or anti -coagulant drugs for 3 days before and after surgery.
2. Subjects that are allergic to lidocaine, epinephrine, valium or sodium phosphate
3. Subjects with skin keloidalis
4. Subjects tested positive for hepatitis B and C, syphilis, HIV
5. Subjects that have had or are suffering from serious diseases, including cancer => Previous history or active serious diseases incl. cancer
6. Women that are pregnant or breast-feeding
7. Subjects that are evaluated as not having the ability to comply with the study.
8. Subjects with an artificial joint replacement on the knee

Study & Design

Study Type: Observational Study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Pain analysis through VAS, 2. Analysis (pain, symptom, function and everyday life, exercise and play function, quality of life) through KOOS, 3.Changing level of pain relief through PV , 4.Changing level of pain relief (the skin temperature in the knee) through temperature test

Secondary Outcome Measures

Name	Time	Method
Condition analysis of joint cartilage through MRI imaging (degree of defect repair and filling of the defect, integration to the border zone of the cartilage, improving level of the damaged structure of cartilage, improving level of adhesion and effusions bone & tissue)