NL-OMON35420招募中不适用
Pathogenesis of community-acquired pneumonia, chronic obstructive pulmonary disease and cystic fibrosis: mechanism of inflammatory response and the role of Th17 differentiation - CCCP
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 135
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 2 至 99（—）
入选标准
- •All patients with COPD, CF or CAP who are admitted to the Erasmus MC will be asked to participate in this study. The treating lung physician will assess eligibility.;COPD
- •- Age >/= 18 years
- •- Diagnosis of COPD according to GOLD criteria (FEV1/FVC<70%), classification into
- •GOLD II (FEV1 50-70% predicted) or GOLD III (FEV1 30- 50% predicted). In case of lungtransplantation: GOLD IV (FEV1 < 30% predicted).
- •- Stable disease. Patients have to be free of COPD exacerbation or respiratory tract
- •infection within a month prior to involvement in the study and they should not have received glucocorticoids or antibiotics in this period.;When patients have to undergo lungtransplantation, they will be asked whether material from their lungs can be used for this study. ;Community-acquired pneumonia
- •- Age >/= 18 years
- •- Clinical presentation of an acute illness with symptoms indicating CAP: fever, dyspnoea,
- •cough, pleuritic chest pain and new consolidations on chest X-ray have to be present.
- •- Normoxemic
- •- In case of hypoxemia (O2 saturation < 92%), patients are only included when patients are intubated and mechanically ventilated, because of respiratory insufficiency.;Cystic fibrosis
- •- Age >/= 18 years
- •- Diagnosis of CF confirmed by sweat-test and/or DNA analysis and/or
- •electrophysiology testing
- •- Stable phase (no signs of exacerbation)
- •- Exacerbation phase: characterized by signs of increased coughing, increased sputum production, dyspnea, fatigue;In some circumstances children with CF have to undergo a bronchoscopy for diagnostic reasons. In these cases we will ask the patients and/or their parents whether some extra material can be obtained from bronchoscopy for this study. Importantly, the children will not be approached to undergo a bronchoscopy, only for scientific reasons!;When patients have to undergo lungtransplantation, they will be asked whether material from their lungs can be used for this study. ;Healthy individuals
- •- Age >/= 18 years
- •- No signs of any disease
- •- Normal Lungfunction
- •- Normal Chest X-ray;In case children with CF are included with age <18 years, then age matched non-CF patients, without signs of inflammation or infection will be included as controls.
排除标准
- •- Hypoxemia (O2 saturation < 92%), unless patients are intubated and mechanically ventilated
- •- Use of antibiotics or glucocorticoids within a month prior to involvement in the study.
研究者
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