Effect of Aged Garlic on Vascular Function and Muscle Oxygenation Responses in the Elderly
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Near infrared spectroscopy 1
研究概览
简要总结
The number of elderly individuals affected by cardiovascular diseases has been increasing in our country. Garlic (Allium sativum) has been associated with decrease of reactive species of oxygen, hypertension, high cholesterol, platelet aggregation, blood coagulation and especially cardiovascular diseases. The present study evaluated the effects of a garlic supplementation on vascular function and blood pressure in the elderly at cardiometabolic risk. Twenty-eight elderly individuals were submitted to an ingestion of four capsules of an aged garlic extract (KYOLIC® Aged Garlic Extract™). Muscle oxygenation and function were measured 180 min after interventions. Urinary thiosulfate, blood nitrate, nitrite, systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were measured at baseline and 180 min after interventions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 60 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cardiometabolic risks
- •Cardiovascular diseases
排除标准
- •HIV positive;
- •Alcohol or drug abuse within the past 6 months previous the visit 1;
- •Garlic allergy;
研究组 & 干预措施
Placebo
Maltodextrin
干预措施: Placebo (Other)
Kyolic® Hi-Po Formula - Kyolic
Aged garlic extract
干预措施: Aged Garlic Extract (Dietary Supplement)
结局指标
主要结局
Near infrared spectroscopy 1
时间窗: 180 minutes after nutritional intervention
microvascular endothelial function
High performance liquid chromatography 2
时间窗: Baseline and 180 minutes after nutritional intervention
Urinary thiosulfate concetrations
High performance liquid chromatography 1
时间窗: Baseline and 180 minutes after nutritional intervention
Urinary nitrate concentrations
Near infrared spectroscopy 2
时间窗: 180 minutes after nutritional intervention
muscle oxygenation saturated assessment
次要结局
未报告次要终点
研究者
Thiago Alvares
Principal Investigator
Universidade Federal do Rio de Janeiro