JPRN-UMIN000032022
Recruiting
未知
Efficacy and safety of corticosteroid monotherapy versus combination therapy of corticosteroid and tacrolimus for patients with anti-aminoacyl-tRNA synthetase antibody-positive polymyositis/dermatomyositis-associated interstitial lung disease: a prospective randomized multicenter clinical trial - Corticosteroid monotherapy versus combination therapy of corticosteroid and tacrolimus for anti-ARS antibody-positive PM/DM-ILD
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- anti-aminoacyl-tRNA synthetase antibody-positive polymyositis/dermatomyositis/clinically amyopathic dermatomyositis-associated interstitial lung disease
- Sponsor
- Hamamatsu University School of Medicine
- Enrollment
- 66
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •Patients who meet the following criteria are excluded from this study: (1\) Patients who requires systemic high dose corticosteroid, immunosuppressants, intravenous immunoglobulin therapy, plasma exchange, or biologic agents for a disease other than PM/DM/CADM\-ILD at the registration (2\) Patients with severe respiratory failure (PaO2 \< 50 Torr) (3\) Patients with contraindication of prednisolone or tacrolimus (4\) Patients with a serious comorbidity (e.g. advanced malignancy, imminent aortic aneurysm, and Liver cirrhosis) (5\) Patients with anti\-MDA5 antibody (6\) Patients who are judged unqualified for this study by attending physician
Outcomes
Primary Outcomes
Not specified
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