To compare the efficacy of two different dosage of cisatracurium for rapid sequence intubation.
Phase 3
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2024/03/063703
- Lead Sponsor
- Sri Venkateswara Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1)American Society of Anesthesiology (ASA) physical status I and II.
2)Patient undergoing elective surgery lasting more than two hours under general anaesthesia.
3)Patients with no known neuromuscular diseases.
4)Patient not undergoing treatment with medications known to interfere with neuromuscular transmission.
5)Patient willing to give the written consent to participate in the study.
Exclusion Criteria
1)Patients who refuse to give consent to the study.
2)Patients who is a known smoker, asthmatic and COPD.
3)Patients with anticipated difficulty airway.
4)Patients with known allergies to the study drug.
5) Pregnant and lactating women.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the time of onset of action of two different doses of cisatracurium for <br/ ><br> rapid sequence induction of anesthesia as an indicator of efficacy. <br/ ><br>Timepoint: 1)Onset of neuromuscular block will be assessed with TOF stimulus every 12 seconds until loss of twitch response (TOF-0). <br/ ><br>2)The blood pressure, heart rate will be recorded every minute for 10 minutes, followed by monitoring every five minutes after endotracheal intubation till the end of surgery. But statistical comparision will be done up to 30 minutes. <br/ ><br>3)After the endotracheal tube fixation, TOF stimulation will be recorded every 5 minutes until the return of two twitches (TOF-25).
- Secondary Outcome Measures
Name Time Method •To compare the duration of action of the two doses of cisatracurium administered for the rapid sequence induction. <br/ ><br>•To compare the intubating conditions during endotracheal intubation using Copenhagen consensus conference scoring system. <br/ ><br>•To compare the hemodynamic changes <br/ ><br>•To document any adverse effects. <br/ ><br>Timepoint: The blood pressure, heart rate and pulse oximetry will be recorded every minute for 10 minutes following induction of anesthesia, followed by monitoring every five minutes after endotracheal intubation till the end of surgery but documentation for statistical comparision will be done up to 30 minutes. <br/ ><br> The time from the onset of muscle relaxation (TOF-0), to the spontaneous recovery time represents the duration of action of the intubating dose of muscle relaxant.