A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Prostate Cancer in East Anglia, Trent and West Midlands
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Cancer Research UK
- Enrollment
- 2,000
- Locations
- 1
- Primary Endpoint
- Evaluation interactions between polymorphisms in predisposition genes and potential lifestyle risk factors
Study Overview
Brief Summary
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This study is looking at genetic susceptibility and the interactions between genes and the environment in patients with prostate cancer.
Detailed Description
OBJECTIVES:
- To obtain epidemiological information and biological material on a population-based series of prostate cancer cases.
- To identify novel cancer susceptibility genes by comparison of genotype frequencies in cases with the corresponding frequencies in large control series.
- To estimate the age and sex-specific risks associated with variants in predisposition genes.
- To evaluate interactions between polymorphisms in predisposition genes and potential lifestyle risk factors.
OUTLINE: This is a multicenter study.
Patients complete a detailed epidemiological questionnaire, including information on education, occupation, smoking habits, alcohol consumption, height, weight, family history of cancer, and past medical history.
Blood samples are collected from patients. DNA is extracted from these blood samples and from samples collected from cancer-free control participants in MREC-SEARCH-CONTROL as well as from additional controls through the European Prospective Investigation of Cancer (EPIC) study (a population based study of diet and health based in Norfolk, East Anglia). DNA samples are analyzed for polymorphisms of low penetrance cancer susceptibility genes.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18 Years to 74 Years (Adult, Older Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Evaluation interactions between polymorphisms in predisposition genes and potential lifestyle risk factors
Acquisition of epidemiological information and biological material
Identification of novel cancer susceptibility genes
Estimation of the age and sex-specific risks associated with variants in predisposition genes
Secondary Outcomes
No secondary outcomes reported