The Role of Progesterone and PIF for Successful Implantation and On-going Pregnancy in Assisted Reproductive Technology

Completed

• Conditions: Infertility
• Interventions: Other: IVF/ICSI treatment

• Registration Number: NCT02129998
• Lead Sponsor: Regionshospitalet Viborg, Skive

Brief Summary

The aim of this study is to achieve a more profound understanding of the endocrine alteration in luteal progesterone level after gonadotrophin stimulated IVF/ICSI cycles and to explore the optimal progesterone level needed for securing implantation and development of early pregnancy.

The second part of the project will determine the value of Preimplantation Factor (PIF) measurement in embryo culture medium as a possible tool for improved embryo selection and the use of PIF as an early pregnancy serum marker for healthy implantation and embryo development.

IVF: In vitro fertilisation, ICSI: Intracytoplasmic sperm injection.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-05
• Study First Submitted: 2014-05-01
• Study First Submitted QC: 2014-05-01
• Study First Posted: 2014-05-02
• Primary Completion: 2017-07
• Status Verified: 2017-10
• Study Completion: 2017-10
• Last Update Submitted: 2017-10-06
• Last Update Posted: 2017-10-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 873

Inclusion Criteria

-All women undergoing IVF/ICSI treatment at the participating clinics in either antagonist protocol or long agonist protocol will be offered participation.

Exclusion Criteria

-Prior participation in the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Standard IVF/ICSI treatment	IVF/ICSI treatment	-

Primary Outcome Measures

Name	Time	Method
On-going pregnancy rate	10th week of gestation

Secondary Outcome Measures

Name	Time	Method
Implantation rate	7th week of gestation

Trial Locations

Locations (1)

The Fertility Clinic Skive; 🇩🇰 Skive, Denmark