A study comparing serum periostin levels in Caucasian and Chinese adult populations without asthma or any other significant respiratory co-morbidity, and comparing serum periostin levels in a Chinese adult population with mild asthma versus moderate/ severe asthma

Not Applicable

Completed

• Conditions: Serum Periostin levels; Public Health - Epidemiology; Respiratory - Asthma

• Registration Number: ACTRN12614000122651
• Lead Sponsor: Medical Research Institute of New Zealand

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-01-31
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 188

Inclusion Criteria

Between 18 to 75 years of age
Able to provide written informed consent
Born in New Zealand, Australia, China, Hong Kong, Taiwan, Singapore or other countries in Asia
Of Chinese descent, more specifically: Both parents that self-identify as ethnic Chinese
Residing in New Zealand for more than one year at Visit 1

For Group 1 (non-asthmatics), at least 10 male and 10 female participants will be recruited to each of the following four age bands; 18-30, 31-45, 46-60 and 61-75 years.
For Group 2 (asthmatics), participants will have a current diagnosis of asthma.
34 will have mild asthma (treated with a SABA) and 34 will have moderate/severe asthma (treated with an ICS).

Exclusion Criteria

Group 1
Doctor’s diagnosis of Asthma, Chronic Bronchitis or COPD
Wheezing or use of respiratory inhalers in the past 12 months
Systemic Corticosteroids within the last three months

Group 1 and 2
Current smoker, or former smoker with a smoking history of greater than 10 pack-years.
Known pregnancy
First six weeks post-partum
Significant co morbidities (determined at investigator discretion)
Hospital admission within last three months
Surgery within last three months, determined at investigator discretion (this includes all major surgery requiring general anaesthetic, dental extractions and root canal procedures. This does not include minor procedures, including but not limited to mole or wart removal, dental fillings etc).
Bone fracture within the last three months
Active (current, or within the three weeks prior to the visit) upper or lower respiratory tract infection
Any other safety concern at the investigator’s discretion

Study & Design

• Study Type: Observational
• Study Design: Not specified