Is there a circadian differential effect of fatigue in multiple sclerosis (MS) on sustained attention performance and EEG frequency patterns?

• Conditions: Fatigue in multiple sclerosis; G35; Multiple sclerosis

• Registration Number: DRKS00024516
• Lead Sponsor: Carl von Ossietzky Universität Oldenburg, Department für Psychologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-02-18
• Study Completion: 2021-11-22
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

a clinically diagnosed MS
- minimum age of 18 years

Exclusion Criteria

- An MS-independent psychiatric disorder that was already known before the diagnosis of MS, i.e. does not have to be considered a direct or indirect consequence of MS.
- Psychoactive medication (noradrenergic antidepressants, modafinil or amantadine).
- Methylprednisolone relapse therapy within the last 4 weeks.
- No sufficient success during the vigilance test, e.g. as a result of a strong decrease of visual acuity, etc.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Performance on the vigilance test will serve as the primary outcome parameter. We expect a difference between the groups (multiple sclerosis with or without fatigue) in the afternoon and not in the morning.

Secondary Outcome Measures

Name	Time	Method
The secondary outcome parameters are VAS and EEG frequency spectrum.