Clinical Observation and MRI Influence of Acupuncture on Knee Osteoarthritis

Not Applicable

Completed

• Conditions: Knee Arthritis Osteoarthritis
• Interventions: Other: acupuncture; Other: physiotherapy

• Registration Number: NCT02446756
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

To observe the therapeutic effect of acupuncture on osteoarthritis(OA) and its efficacy on cartilage restoration,acupuncture and physiotherapy treatment were respectively given to two random groups. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was used to evaluate the motor function of knee joints, followed by magnetic resonance imaging (MRI) scanning to measure T2 values in ten cartilage sub-regions in tibiofemoral joints.

Detailed Description

To observe the therapeutic effect of acupuncture on osteoarthritis and its efficacy on cartilage restoration,one hundred knees of 50 patients with knee osteoarthritis were randomly divided into acupuncture group and physiotherapy group which were respectively received acupuncture and physiotherapy treatment for four weeks. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was used to evaluate the motor function of knee joints, followed by magnetic resonance imaging (MRI) scanning to measure T2 values in ten cartilage sub-regions in tibiofemoral joints.

Study Timeline

• Study Start: 2010-01
• Primary Completion: 2013-07
• Study Completion: 2014-02
• Status Verified: 2015-05
• Study First Submitted: 2015-05-06
• Study First Submitted QC: 2015-05-13
• Last Update Submitted: 2015-05-13
• Study First Posted: 2015-05-18
• Last Update Posted: 2015-05-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Clinically diagnosed as knee osteoarthritis according to the OA criteria proposed by American College of Rheumatology in 1995.

Exclusion Criteria

• Acute knee injury
• Had ever accepted therapy as hormone or injection in articulation cavity
• Had ever accepted treatment as oral medicine, physiotherapy, acupuncture or massage during the passed three months
• Had planted cardiac pacemaker or any metal matter in body
• Other severe diseases such as heart, lung, liver, kidney or cerebrum failure, tumors, gastrointestinal hemorrhage and so on
• Pregnant or lactating woman
• Anyone unable to tolerate or cooperate with treatment.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
acupuncture group	acupuncture	Acupuncture treatment was given once every other day and 20min each time for four weeks.
physiotherapy group	physiotherapy	Physiotherapy treatment was given five times a week and 30min each time for four weeks.

Primary Outcome Measures

Name	Time	Method
WOMAC scores	up to 24 months
T2 Values	up to 30 months