NCT04739748已完成不适用
Prognostic Biomarkers in Predicting Mortality in Respiratory Patients With Ventilator-Associated Pneumonia
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 136
- 试验地点
- 1
- 主要终点
- Hospital Mortality
研究概览
简要总结
The aim of this study is to evaluate prognostic efficiency RDW and NLR for mortality prediction in respiratory patients with VAP.
详细描述
Ventilator-associated pneumonia (VAP) is the most common nosocomial infection. VAP continues to be a leading cause of morbidity and mortality in the nosocomial setting. Red cell distribution width (RDW) and neutrophil-lymphocyte ratio (NLR) are prognostic factors to mortality in different diseases.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Respiratory failure needs mechanical ventilator support > 48 hrs. VAP was defined as an acute lower respiratory tract infection in mechanically ventilated patient > 48 hrs with a new or progressing infiltrate on chest radiograph and who met at least two of the following clinical criteria: body temperature >38°C or <36°C with no other recognized cause, white blood cell count >10,000 /mm3 or <5000 /mm3, or a macroscopically purulent tracheal aspirate
- •Only the first VAP episode was included
排除标准
- •Neutropenia (< 500 cells/ml) before the development of VAP.
- •Conditions are known to influence total and differential WBC counts such as chronic inflammatory conditions, hematologic disorders, history of chemotherapy, or radiotherapy within 4 weeks before enrollment.
- •Conditions are known to affect RDW as anemia due to nutritional deficiency (ie, iron, vitamin B12, and folic acid).
- •Patients with HIV/AIDS
结局指标
主要结局
Hospital Mortality
时间窗: 45 days
The number of patients who not Survive after developing ventilator-associated pneumonia in their stay in the Respiratory Intensive Care Unit.
次要结局
未报告次要终点
研究者
Nermeen Aly Mahmoud Abdel Aleem
lecture in Faculty of medicine,Assiut University
Assiut University
研究点 (1)
Loading locations...
相似试验
尚未招募
不适用
CRP,CRP/Alb Ratio, N/L Ratio in Predictors of Both Systemic Infection and Survival in Patient with Sepsis in Assiut University HospitalsSystemic InfectionSepsisNCT06586372Assiut University100
已完成
不适用
Investigation of biomarkers for predicting the response to steroids in patients with COPDCOPDJPRN-UMIN000010711Third Department of Internal Medicine, Wakayama Medical University80
已完成
不适用
Red Cell Distribution Width (RDW) as a Prognostic Marker in ICUBiochemical MarkerBlood TransfusionNCT02917811Università degli Studi di Ferrara250
招募中
不适用
Biomarkers in Retinitis PigmentosaRetinitis PigmentosaNCT06306690Fondazione Policlinico Universitario Agostino Gemelli IRCCS35
招募中
不适用
Triage - Symptoms and Other Predictors in an All-comer Emergency Department PopulationTriage Risk StratificationNCT05400707University Hospital, Basel, Switzerland6,467