MRSA decolonization in complicated carriage - cluster randomized trial

Recruiting

Conditions: MRSA carriership - Methicillin resistant Staphylococcus aureus carriership
10004018

Registration Number: NL-OMON51735

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 201

Inclusion Criteria

complicated MRSA carriership
Adult

Exclusion Criteria

- catheters/drains in situ
- Failure of previous decolonization attempt of complicated MRSA carriage
- Allergy or other contra-indication to either doxycycline, rifampicin or
trimethoprim (these patients will participate in the observational arm)
- Previous participation in this study
- Pregnancy

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study endpoint is the success rate of MRSA decolonization. Successful<br /><br>decolonization is defined as 3 consecutive negative cultures after treatment,<br /><br>with a minimum interval of 7 days. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- The long-term success rate of decolonization treatment of<br /><br>doxycycline-rifampicin compared to trimethoprim-rifampicin, defined as an<br /><br>additional set of negative MRSA swabs taken 2 months and 1 year after<br /><br>decolonization treatment.<br /><br><br /><br>- To determine whether there is an association between virulence factors and<br /><br>success rate of decolonization. </p><br>