Survival Among Patients With Pancreatic Cancer Depending on Surgical Resection Rate

Completed

• Conditions: Pancreatic Ductal Adenocarcinoma
• Interventions: Other: Resection rates

• Registration Number: NCT04802993
• Lead Sponsor: Linkoeping University

Brief Summary

The primary aim of this population-based study is to investigate how a high resection rate of pancreaticoduodenectomy affects overall survival among patients aged ≥70 years with pancreatic ductal adenocarcinoma. The secondary aim is to determine if a high resection rate of pancreaticoduodenectomy increases perioperative morbidity.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01-01
• Primary Completion: 2020-10-02
• Study Completion: 2020-10-02
• Status Verified: 2021-03
• Study First Submitted: 2021-03-15
• Study First Submitted QC: 2021-03-15
• Last Update Submitted: 2021-03-15
• Study First Posted: 2021-03-17
• Last Update Posted: 2021-03-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 5123

Inclusion Criteria

• Diagnosed between 1 January 2010 and 31 December 2018
• Registered in the Swedish National Registry for tumours in the pancreatic and periampullary region
• Either a diagnosis of pancreatic ductal adenocarcinoma of the pancreatic head or having been resected with pancreaticoduodenectomy

Exclusion Criteria

• None

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
All patients with pancreatic ductal adenocarcinoma aged 70-79 years	Resection rates	All patients in the registry aged 70-79 years with right-sided pancreatic ductal adenocarcinoma
All patients resected with pancreaticoduodenectomy, aged 80 years and older	Resection rates	All patients in the registry resected with pancreaticoduodenectomy during the study period, aged 80 years and older
All patients with pancreatic ductal adenocarcinoma aged 80 years and older	Resection rates	All patients in the registry aged 80 years and older with right-sided pancreatic ductal adenocarcinoma
All patients resected with pancreaticoduodenectomy, all ages	Resection rates	All patients in the registry resected with pancreaticoduodenectomy during the study period
All patients with pancreatic ductal adenocarcinoma aged 70 years and older	Resection rates	All patients in the registry aged 70 years and older with right-sided pancreatic ductal adenocarcinoma
All patients resected with pancreaticoduodenectomy, aged 70-79 years	Resection rates	All patients in the registry resected with pancreaticoduodenectomy during the study period, aged 70-79 years

Primary Outcome Measures

Name	Time	Method
Overall survival	A little more than 10 years (from first patient to vital status)	Overall survival among patients aged 70 years and over with pancreatic ductal adenocarcinoma in the pancreatic head

Secondary Outcome Measures

Name	Time	Method
Severe complications after pancreaticoduodenectomy	Around 10 years (patients diagnosed between 1 January 2010 and 31 December 2018, latest dismissal from hospital january 2020)	The rate of severe complications among patients aged 70 years and over who had undergone pancreaticoduodenectomy for any reason