The Mechanisms of Cortico-cortical and Cortico-subcortical Networks in Methamphetamine Addiction by Paired Associative Stimulation
试验速览
- 阶段
- 不适用
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Change of working memory
研究概览
简要总结
The investigators use paired associative stimulation (PAS) protocols to target cortico-cortical and cortico-subcortical networks to study cognitive deficits in methamphetamine addiction.
详细描述
Paired associative stimulation (PAS) is a form of transcranial magnetic stimulation in which paired pulses can induce plasticity at cortical synapses, producing long-term potentiation (LTP) or long-term depression (LTD) effect. The investigators use paired associative stimulation (PAS) protocols to target cortico-cortical and cortico-subcortical networks (frontoparietal control pathway) by using different intervals between the paired pulses to explore the mechanism of cognitive deficits in methamphetamine addiction. The investigators hypothesize that different temporal sequences of cortical stimulation could produce facilitation or inhibition effect.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •In accordance with the Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) for methamphetamine (MA) use disorders
- •Junior high school degree or above
- •Normal vision and hearing
- •Dextromanual
排除标准
- •Have a disease that affect cognitive function such as history of head injury, cerebrovascular disease, epilepsy, etc
- •Have cognitive-promoting drugs in the last 6 months
- •Other substance abuse or dependence in recent five years (except nicotine)
- •Mental impairment, Intelligence Quotient (IQ) < 70
- •Mental disorders
- •Physical disease
研究组 & 干预措施
DLPFC+10 IPL
Stimulation of dorsolateral prefrontal cortex (DLPFC) 10 ms before inferior parietal lobule (IPL) presumes that the DLPFC to IPL input facilitates insula postsynaptic output activity, thereby improving cognition response via a long term potentiation-like effect.
干预措施: MagPro X100 device (MagVenture, Farum, Denmark) (Device)
IPL+10 DLPFC
Stimulation of IPL 10 ms before DLPFC presumes that the IPL to DLPFC input inhibits insula postsynaptic output activity, thereby impairing cognition response via a long term depression-like effect.
干预措施: MagPro X100 device (MagVenture, Farum, Denmark) (Device)
IPL+4 DPLFC
Stimulation of IPL 4 ms before DLPFC is presumed to be too brief for a corticocortical effect but presumes that the DLPFC input to insula inhibits insula postsynaptic output by weakening the IPL to insula input, thereby impairing cognition response.
干预措施: MagPro X100 device (MagVenture, Farum, Denmark) (Device)
DLPFC+4 IPL
Stimulation of DLPFC 4 ms before IPL is presumed to be too brief for a corticocortical effect but presumes that the DLPFC input to insula potentiates insula postsynaptic output by strengthening the IPL to insula input, thereby improving cognition response.
干预措施: MagPro X100 device (MagVenture, Farum, Denmark) (Device)
DLPFC+4 MPFC
Stimulation of DLPFC 4 ms before medial prefrontal cortex (MPFC) presumes that the DLPFC input facilitates MPFC postsynaptic output activity, thereby improving cognition response via a long term potentiation-like effect.
干预措施: MagPro X100 device (MagVenture, Farum, Denmark) (Device)
MPFC+4 DLPFC
Stimulation of MPFC 4 ms before DLPFC presumes that the DLPFC input inhibits MPFC postsynaptic output activity, thereby impairing cognition response via a long term depression-like effect.
干预措施: MagPro X100 device (MagVenture, Farum, Denmark) (Device)
DLPFC+10 MPFC
Stimulation of DLPFC 10 ms before medial prefrontal cortex (MPFC) presumes that the DLPFC input facilitates MPFC postsynaptic output activity, thereby improving cognition response via a long term potentiation-like effect.
干预措施: MagPro X100 device (MagVenture, Farum, Denmark) (Device)
MPFC+10 DLPFC
Stimulation of MPFC 10 ms before DLPFC presumes that the DLPFC input inhibits MPFC postsynaptic output activity, thereby impairing cognition response via a long term depression-like effect.
干预措施: MagPro X100 device (MagVenture, Farum, Denmark) (Device)
结局指标
主要结局
Change of working memory
时间窗: 30 minutes
The N-Back is a working memory task where the subject is presented with a sequence of stimuli (letters). The task consists of indicating when the current stimulus matches the one from n steps earlier in the sequence.
Change of response inhibition
时间窗: 30 minutes
Response inhibition was assessed with the SST (Cambridge Cognition, Cambridge, UK). The subject responded to an arrow (go signal), pointing either right or left, by pressing one of two buttons with the right or left index finger. If an audio tone (stop signal) was present, the subject needed to withhold the response.
Change of attention bias
时间窗: 30 minutes
During the dot-probe task, participants are situated in front of a computer screen with their chin securely placed on a chin rest. Participants are asked to stare at a fixation cross on the center of the screen. Two stimuli, one of which is neutral and one of which is threatening, appear randomly on either side of the screen. The stimuli are presented for a predetermined length of time (most commonly 500ms), before a dot is presented in the location of one former stimulus. Participants are instructed to indicate the location of this dot as quickly as possible, either via keyboard or response box.
Change of risk decision
时间窗: 30 minutes
The Balloon Analogue Risk Task (BART) is a computerized measure of risk taking behavior. In the task, the participant is presented with a balloon and offered the chance to earn money by pumping the balloon up by clicking a button. Each click causes the balloon to incrementally inflate and money to be added to a counter up until some threshold, at which point the balloon is over inflated and explodes.
次要结局
- Change of motor evoked potential(30 minutes)
- Change of resting motor threshold(30 minutes)
- Change of eeg oscillatory (Alpha, Beta, Theta and Delta)(30 minutes)
- Change of eeg functional connectivity (Alpha, Beta, Theta and Delta)(30 minutes)
研究者
Haifeng Jiang
associate chief physician
Shanghai Mental Health Center