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临床试验/NCT04446364
NCT04446364Unknown不适用

Ethanolic Extract of Aloe Vera Versus Chlorohexidine as Cavity Disinfectant: A Split-mouth Randomized Clinical Trial

Cairo University0 个研究点目标入组 32 人开始时间: 2020年9月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
32
主要终点
Bacterial reduction

研究概览

简要总结

This Randomized Clinical Trial will be conducted to compare the efficacy of ethanolic extract of Aloe vera versus chlorhexidine cavity disinfectant in reducing total bacterial count of Streptococcus mutans (SM) and Lactobacilli (LB).

详细描述

Dental caries remains to be a major oral health problem afflicting people, young and old, especially in developing and underdeveloped countries. Though dentistry has magically developed with newer materials and newer techniques, dental caries remains a disease of great prevalence.

The prevention and control of caries necessitates the elimination of cariogenic bacteria that produce acids responsible for the decrease of pH and starting the process of demineralization.

While the goal of restorative treatments for dental caries is to remove the infected dentin and fill the area with a suitable restorative material, failure to remove the infected teeth surface totally and achieve complete sterilization of the cavity can lead to microleakage, increased pulp sensitivity, pulpal infection and secondary caries that necessitate replacement of restoration.

Therefore, after removal of the carious dentin it is important to eliminate any remaining bacteria that may be present on the cavity walls, in the smear layer, at the enamel-dentin junction, or in the dentinal tubules. But unfortunately, no definitive and reliable criteria are available to ensure the complete removal of carious tooth structure. Many investigations have shown the presence of bacteria in the dentin even after removal of dye-stainable dentin.

Due to indiscriminate use of antimicrobials more and more pathogens are becoming resistant and posing a serious threat in rendering successful treatment of the diseases. With the rise in bacterial resistance to various synthetic antimicrobial agents, there is a considerable interest and a growing trend in the field.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

入排标准

年龄范围
20 Years 至 50 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • • Patients with at least two occlusal deep carious lesions, one on each side, preferred from the same arch.
  • Age range 20-50 years.
  • Systematically health.
  • Adults who were able to give informed consent.
  • Teeth with radiographic evidence of carious lesion that penetrated at least the inner one half of the dentin thickness.

排除标准

  • • Patients with clinical and radiographic signs of pulpal involvement.
  • Patients unable to return for recall appointments.
  • Inability of a patient to give informed consent.
  • Teeth with clinical and radiographic sign of pulpal involvement.
  • Teeth where isolation with a rubber dam was not possible

结局指标

主要结局

Bacterial reduction

时间窗: one year

Reduction of total bacterial count of SM and LB. IT will be measured before and after cavity disinfectant.

次要结局

  • Pulp vitality(one year)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Sara Ibrahim Ahmed Hedia

Master degree studnet, Conservative Dentistry Department, Faculty of Dentistry, Cairo University.

Cairo University

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