The Interactive Effects Of Beta-Alanine Supplementation and Resistance Training on Muscular Endurance in Older Adults
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Miami
- Enrollment
- 27
- Locations
- 1
- Primary Endpoint
- Change in Performance of Daily Activities
Study Overview
Brief Summary
The purpose for this study is to determine if beta-alanine supplementation combined with endurance-based resistance training can increase gains in muscular endurance to a greater extent than endurance-based resistance-training alone in older adults.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 60 Years to 90 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •60-90 years of age
- •Living independently (not residing in an assisted living facility)
- •Through testing are found not to have sarcopenia
- •Gait speed > 1 m/s
- •Skeletal Muscle Index > 37% in men and > 27.6 % in women
Exclusion Criteria
- •Responding with a "yes" to any question on the PAR-Q.
- •Are currently pregnant, or plan to try and become pregnant during the study
- •Functional impairments that could impede the person's ability to participate in a resistance training program
- •Current or recent use of supplements (within the past 3 months for non-alanine containing supplements or one year for supplements containing beta-alanine). Individuals taking only basic multivitamins (without any herbal co-ingredients) may still be allowed to participate. These situations will be reviewed on a case-by-case basis.
- •Are currently enrolled in a regular exercise program (more than once per week)
- •Current or recent smoker
- •Use of medication containing corticosteroids
- •Mini-mental score of 21 or below
- •Severe musculoskeletal impairment
- •Uncontrolled chronic disease
- •Major depression
- •Severe vestibular problems
- •Exclusion Criteria:
- •Adults unable to consent
- •Individuals who are not yet adults (infants, children, teenagers)
- •Pregnant women
- •Prisoners
Arms & Interventions
Placebo without muscular endurance training
Receive similar dextrose placebo with no endurance resistance training for 12 weeks
Intervention: Placebo (Dietary Supplement)
Beta-alanine and muscular endurance exercise
Receive 3.2 g/day beta-alanine and 3 days per week of endurance resistance training for 12 weeks
Intervention: Muscular endurance exercise (Behavioral)
Placebo and muscular endurance exercise
Receive similar dextrose placebo and 3 days per week of endurance resistance training for 12 weeks
Intervention: Placebo (Dietary Supplement)
Placebo and muscular endurance exercise
Receive similar dextrose placebo and 3 days per week of endurance resistance training for 12 weeks
Intervention: Muscular endurance exercise (Behavioral)
Beta-alanine without muscular endurance training
Receive 3.2 g/day beta-alanine with no endurance resistance training for 12 weeks
Intervention: Beta-alanine (Dietary Supplement)
Beta-alanine and muscular endurance exercise
Receive 3.2 g/day beta-alanine and 3 days per week of endurance resistance training for 12 weeks
Intervention: Beta-alanine (Dietary Supplement)
Outcomes
Primary Outcomes
Change in Performance of Daily Activities
Time Frame: baseline, 12 weeks
Short Physical Functional Performance test
Secondary Outcomes
- Change in Body Fat(baseline, 12 weeks)
- Change in Muscular Endurance(baseline, 12 weeks)
- Change in Muscular Strength(baseline, 12 weeks)
Investigators
Joseph Signorile
Professor
University of Miami