Alterations in Corticospinal and Neuromuscular Control of Shoulder Complex in Office Workers With Non-specific Chronic Neck Pain
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 51
- 试验地点
- 2
- 主要终点
- Neurophysiological measures - Motor evoked potential
研究概览
简要总结
Non-specific chronic neck pain (NCNP) is commonly seen in office workers. Individuals with NCNP not only demonstrate impaired neck movement control and muscle activation, but also show abnormal scapular kinematics and muscle activation timing. Office workers with NCNP also show higher activity of upper trapezius during computer typing and have difficulty relaxing upper trapezius after typing. These changes related to scapula may increase strain over neck. In addition to the altered neuromuscular control, recent studies found neuroplasticity changes in the central nervous system on patients of chronic musculoskeletal disorders. Therefore, few studies found shifts and alterations of motor cortex representation of neck muscles in individuals with NCNP, which was correlated with delayed muscle activation of deep neck flexors muscle in functional activities. However, no studies have explored that whether this corticospinal adaptation also happens over scapular muscles, especially after a computer typing task. The objectives of this proposal are to investigate the differences in corticospinal and neuromuscular control of shoulder complex between office workers with and without NCNP. Thirty-five individuals with NCNP and 35 healthy controls will be recruited. Twenty young healthy subjects will be also recruited for a pilot study to test the reliability of all the measures. Scapular kinematics and muscle activation will be tested during arm elevation. Corticospinal parameters of trapezius and serratus anterior will be tested with transcranial magnetic stimulation (TMS), including active motor threshold, motor evoked potential, cortical silent period, short interval intracortical facilitation, short interval intracortical inhibition and cortical mapping. Corticospinal parameters, except cortical mapping, will be measured again after a 30-minute computer typing task. Scapular muscle activation will be also recorded during the typing task.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Neurophysiological measures - Motor evoked potential
时间窗: Change from baseline MEP after 30-minute computer typing task or 30-minute rest
Motor evoked potential (MEP) will be described with millivolt (mV).
Neurophysiological measures - Cortical silent period
时间窗: Change from baseline CSP after 30-minute computer typing task or 30-minute rest
Cortical silent period (CSP) will be measured with millisecond (ms)
Neurophysiological measures - Center of gravity of cortical mapping
时间窗: Change from baseline center of gravity of cortical mapping of cortical mapping after 30-minute rest (pilot subjects)
Center of gravity of cortical mapping will be described in a x-y coordinate system (mm).
Neurophysiological measures - Active motor threshold
时间窗: Change from baseline AMT after 30-minute computer typing task or 30-minute rest
Active motor threshold (AMT) will be described with the percentage (%) of maximum stimulator output (MSO).
Neurophysiological measures - Volume of cortical mapping
时间窗: Change from baseline volume of cortical mapping after 30-minute rest (pilot subjects)
Volume of cortical mapping will be calculated with multiplying summation of motor evoke potentials on the map (mV) by the area of the map (mm2) with the unit of mV\*mm2
Neurophysiological measures - Short interval cortical facilitation
时间窗: Change from baseline SICF after 30-minute computer typing task or 30-minute rest
Short interval cortical facilitation (SICF) will be defined as percentage (%) of conditioning responses vs testing responses while the inter-stimulus interval is above 5 ms
Neurophysiological measures - Area of cortical mapping
时间窗: Change from baseline area of cortical mapping after 30-minute rest (pilot subjects)
Area of cortical mapping will be described with square millimeter (mm2)
Neurophysiological measures - Short interval cortical inhibition
时间窗: Change from baseline SICI after 30-minute computer typing task or 30-minute rest
Short interval cortical inhibition (SICI) will be defined as percentage (%) of conditioning responses vs testing responses while the inter-stimulus interval is below 5 ms
次要结局
- Scapular kinematics during arm elevation(Change from baseline scapular kinematics after 30-minute rest (pilot subjects))
- Scapular muscles activation during performing the computer task(Change from baseline during the 30-minute computer typing task at 5, 10, 15, 20, 25, 30 minutes of the task)
- Scapular muscles activation during arm elevation(Change from baseline scapular muscles activation after 30-minute rest (pilot subjects))
- Craniovertebral angle(Change from baseline craniovertebral angle after 30-minute rest (pilot subjects))
- Scapular kinematics during performing the computer task(Change from baseline during the 30-minute computer typing task at 5, 10, 15, 20, 25, 30 minutes of the task)
研究者
Yin-Liang Lin
Assistant Professor
National Yang Ming Chiao Tung University