Effect of Curcumin Supplementation on Oxidative stress in transfusion dependant Pediatric Beta thalassemia Patients
Phase 2
- Conditions
- Health Condition 1: D561- Beta thalassemia
- Registration Number
- CTRI/2023/10/058939
- Lead Sponsor
- Dr Vijay Kalrao
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Subjects whose age is 5 to 18 years
Patients who have been diagnosed with homozygous beta thalassemia on the basis of severe anaemia and HPLC
Patients who receive packed cell RBC transfusions approximately every month.
Duration of transfusion should be 6 months or more
Exclusion Criteria
Acute illness, comorbidities such as Type 1 Diabetes and/or Sickle cell.
Patients taking any health supplements apart from folic acid within the past 3 months
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Decrease in Serum Malondialdehyde levels in test group vs control group <br/ ><br> <br/ ><br>Increase in Total Antioxidant Capacity levels in Test group vs Control groupTimepoint: Pre Intervention vs Post intervention (intervention applied for 3 months)
- Secondary Outcome Measures
Name Time Method decreased mean levels of ferritin and increased mean levels of serum iron, transferrin, total iron binding capacity before and after curcumin supplementation <br/ ><br>Timepoint: Pre Intervention vs Post intervention (intervention applied for 3 months)