Efficacy of the Apitherapy in the treatment of recalcitrant localized plaque psoriasis and evaluation of Tumor Necrosis Factor-Alpha (TNF-a) serum level: Double blind randomized clinical trial.

Phase 3

Completed

• Conditions: ocalized psoriasis; Inflammatory and Immune System - Autoimmune diseases; Localized psoriasis; Skin - Dermatological conditions

• Registration Number: ACTRN12613001028796
• Lead Sponsor: Faculty of Medicine, Suez Canal University, prof. Atef Elakhras

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-09-16
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

*Patients diagnosed as recalcitrant localized psoriasis.
*Patients aged 18 -60 years.
*Both genders.
*Stopping any topical or systemic treatment for psoriasis during the last 2 months.

Exclusion Criteria

*Patient who had any allergic disorder.
*Patient who had reactions to bee stings.
*Patient who are responding well to conventional treatment.
*Pregnancy and lactation.
*Systemic diseases such as diabetes and cardiac diseases

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To evaluate the therapeutic potential effect of Bee venom in recalcitrant localized Psoriasis, by assessing Physician Global Assessment (PGA) before and after treatment[To evaluate the therapeutic potential effect of Bee venom in recalcitrant localized Psoriasis at the end of 3 months of treatment];To evaluate the therapeutic potential effect of Bee venom in recalcitrant localized Psoriasis at the end of 3 months of treatment. By assessing with physician global assessment (PGA).[To evaluate the therapeutic potential effect of Bee venom in recalcitrant localized Psoriasis at the end of 3 months of treatment]

Secondary Outcome Measures

Name	Time	Method
To detect the effect of Bee venom on the serum level of Tumor necrosis factor alpha (TNF-a).[To detect the effect of Bee venom on the serum level of Tumor necrosis factor alpha (TNF-a).by measuring serum level of (TNF-a) at the beginning and 12th week of treatment via polystyrene microplate ELISA]