The Influence of Probiotics on Vancomycin-Resistant Enterococcus

Not Applicable

Terminated

• Conditions: GI Colonization of Vancomycin-resistant Enterococcus
• Interventions: Dietary Supplement: yogurt; Dietary Supplement: probiotics

• Registration Number: NCT00591474
• Lead Sponsor: Oregon Health and Science University

Brief Summary

Drinking probiotics in a the form of a yogurt drink will restore normal gastrointestinal (GI) bacteria in patients whose colon are colonized with vancomycin-resistant enterococcus (VRE).

Detailed Description

Not available

Study Timeline

• Study Start: 2007-12
• Study First Submitted: 2007-12-28
• Study First Submitted QC: 2008-01-10
• Study First Posted: 2008-01-11
• Primary Completion: 2010-01
• Study Completion: 2010-06
• Status Verified: 2019-05
• Last Update Submitted: 2019-05-31
• Last Update Posted: 2019-06-04

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

• VRE positive patients with GI colonization

Exclusion Criteria

• Age less than 18 years
• Patients who have had a bone marrow transplant
• Extreme short bowel patients (less than 100 cm small bowel remaining)
• Patients with active VRE infection but no GI colonization
• Patients unable to eat and have no feeding access
• Patients who do not have a power of attorney to give consent if they are unable to

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
2	yogurt	VRE positive patients
1	probiotics	VRE positive patients

Primary Outcome Measures

Name	Time	Method
Whether a positive VRE colonized patient becomes VRE negative after drinking yogurt with probiotics	4 weeks

Secondary Outcome Measures

Name	Time	Method
Any positive or negative effects on patients' hospital stay.	8 weeks
Time to VRE clearance	4 weeks
Sustainable effects of probiotics on VRE colonization	8 weeks

Trial Locations

Locations (1)

OHSU hospital; 🇺🇸 Portland, Oregon, United States