Effectiveness of Interrupted Light Therapy in Deeply Jaundiced Neonates
- Conditions
- Health Condition 1: P598- Neonatal jaundice from other specified causes
- Registration Number
- CTRI/2023/09/057921
- Lead Sponsor
- Maulana Azad Medical College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1.Gestational age more than or equal to 35 weeks, if not ascertainable admission weight >2.4 kg.
2.Clinical jaundice appearing after 24 h of life.
3.Babies with total serum bilirubin (TSB) in the phototherapy range as per
clinical Practice Guidelines AAP 2022
4. TSB <2mg/dl below the threshold for exchange transfusion.
5.Rate of rise of TSB after 6 hours of initial phototherapy less than or equal to
0.2mg/dl/h
1.Major congenital malformations
2.Babies having neurotoxicity risk factors before enrollment(CPG AAP 2022)
a) Serum albumin <3gm/dL
b)Isoimmune hemolytic disease
c)Sepsis(sepsis requiring treatment with antibiotic)
d)Clinical instability in previous 24 hours(cardiopulmonary instability,hypotension requiring pressure support, blood PH <7.15,any respiratory support,sepsis)
3.Direct bilirubin more than 15% or more than 1.5mg/dL of TSB.
4.Baby received PT for more than 5 h before admission.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Rate of fall of TSB measured as mg/dL/h and mg/dL/h/mg of TSB after initial 24 hours of PTTimepoint: 0-28 days
- Secondary Outcome Measures
Name Time Method Baby developing BIND(bilirubin induced neurological dysfunction)Timepoint: 0-28 days;Baby requiring escalation of care during phototherapyTimepoint: 0-28 days;Baby requiring Exchange transfusionTimepoint: 0-28 days;Change in Platelet countTimepoint: 0-28 days;Change in serum Electrolytes (sodium,potassium,calcium)Timepoint: 0-28 days;Rate of rise of TSB measured as mg/dL/h and mg/dL/h/mg of TSB during entire duration of PTTimepoint: 0-28 days;Rate of rise of TSB more than or equal to 0.2mg/dl/hrTimepoint: 0-28 days;Rebound of TSB at 12 h of discontinuation of phototherapyTimepoint: 0-28 days