Comparison of Prognosis Between Open Pancreatic Surgery With Vein Resection and Reconstruction Versus Minimally Invasive Pancreatic Surgery With Vein Resection and Reconstruction for Pancreatic Cancer: A Multicenter Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2,451
- 试验地点
- 1
- 主要终点
- incidences of postoperative thrombosis
研究概览
简要总结
The prognostic differences between open and minimally invasive radical pancreatic surgery combined with venous resection and reconstruction remain controversial, and there is a lack of high-quality evidence-based medical evidence to support either approach. Therefore, this study intends to conduct a retrospective cohort analysis, planning to enroll pancreatic cancer patients who have undergone radical pancreatic surgery (open vs. minimally invasive) combined with venous resection and reconstruction from multiple hospitals both domestically and internationally, and to collect relevant data. The primary objective is to evaluate the differences in postoperative thrombosis and the incidence of severe complications between the two groups. Furthermore, prognostic data will be collected to assess the impact of open versus minimally invasive pancreatic surgery combined with venous resection and reconstruction on both short-term and long-term all-cause mortality in pancreatic cancer patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosis of malignant pancreatic or periampullary lesions requiring surgical pancreatic resection; preoperative imaging confirming venous involvement; undergoing pancreatic resection with simultaneous venous resection and reconstruction; and availability of complete postoperative outcome data, including thrombosis and complication grading.
排除标准
- •preoperative confirmation of distant metastasis.
研究组 & 干预措施
Open
The open pancreatic surgery with venous resection and reconstruction cohort
MIS
The minimally invasive pancreatic surgery with venous resection and reconstruction cohort
结局指标
主要结局
incidences of postoperative thrombosis
时间窗: within 30 postoperative days
incidences of major complication
时间窗: within 30 postoperative days
Postoperative complications were defined and graded according to the Clavien-Dindo (C-D) classification system ranging from Grade I (minor deviation) to Grade V (death), with C-D ≥III being considerated as major complication
次要结局
- incidence of postoperative pancreatic fistula(within 30 postoperative days)
- incidence of postoperative delayed gastric emptying(within 30 postoperative days)
- incidence of postoperative post-pancreatectomy hemorrhage(within 30 postoperative days)
- postoperative overall survival(before discharge, and at 3, 6, 12, 18, 24, 30, and 36 months postoperatively)
- postoperative recurrence-free survival(before discharge, and at 3, 6, 12, 18, 24, 30, and 36 months postoperatively)