Early versus late antiretroviral therapy in HIV positive adults
- Conditions
- Health Condition 1: null- HIV positive patientsHealth Condition 2: B20- Human immunodeficiency virus [HIV]disease
- Registration Number
- CTRI/2018/05/013784
- Lead Sponsor
- Department of Health Research Ministry of Health Family Welfare ICMR
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
HIV infected patient in the age group >18 years belonging to male, female and transgender
1.HIV infected patient in age group < 18 years.
2.Current pregnancy or breastfeeding (a negative serum or urine pregnancy test is required within 14 days before randomization for women of child-bearing potential)
3. Current imprisonment, or compulsory detention (involuntary incarceration) for treatment of a psychiatric or physical illness.
4.Cardiovascular event (myocardial infarction, angioplasty, coronary-artery bypass grafting, stroke) within 6 months before randomization
5. Non-AIDS-defining cancer, excluding basal and squamous cell skin cancer, within six months before randomization
6.Dialysis within six months before randomization
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.To compare the effects of early and delayed initiation of antiretroviral therapy on clinical outcomes of HIV positive adults <br/ ><br>2.To assess the effect of early initiation of antiretroviral therapy on immunological status of HIV positive adults using CD4 count as surrogate marker. <br/ ><br>3.To evaluate health related quality of life (HRQOL) of HIV/AIDS patients using world health organization quality of life- HIV brief instrument (WHOQOL-HIV BREF).Timepoint: 9 months
- Secondary Outcome Measures
Name Time Method 1.Adverse drug reactions to antiretroviral drugs <br/ ><br>2. Progression to AIDS <br/ ><br>3. Survival rateTimepoint: 9 months