Analysis of Sublingual Glycocalyx Damage at ICU Admission to Predict Risk of Death - the ASGARD Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Predictive value of glycocalyx thickness regarding mortality.
研究概览
简要总结
The aim of this observative, prospective study is to evaluate if and to what extent glycocalyx damage/microcirculation data at admission in the ICU as well as during ICU stay can be predictive of mortality and clinical course in patients presenting with the suspicion of sepsis/septic shock. Therefore, the enrollment of ca 100 ICU patients is planned.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ICU patients admitted to the ICU with the clinican suspicion of sepsis/septic shock.
排除标准
- •Underage persons, pregnant women, patients with inflammation or trauma of sublingual mucosa.
结局指标
主要结局
Predictive value of glycocalyx thickness regarding mortality.
时间窗: Hospital stay, an expected time of 4 weeks.
Glycocalyx thickness measured with the use of GlycoCheck System (Perfused Boundary Region - PBR, in µm).
Predictive value of glycocalyx thickness regarding clinical course.
时间窗: Hospital stay, an expected time of 4 weeks.
Glycocalyx thickness measured with the use of GlycoCheck System (Perfused Boundary Region - PBR, in µm). Clinical course will be estimated with the use of e.g. Sequential Organ Failure Assessment (SOFA) score (in points).
次要结局
- Correlation of glycocalyx thickness with disease severity.(Hospital stay, an expected time of 4 weeks.)