Human Microbiome and Healthcare Associated Infections - Nursing Home Dwelling Older Veterans
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 2
- 主要终点
- Change in the Abundance of Staphylococcus Aureus in the Nose After Decolonization
研究概览
简要总结
The purpose of the research is to find out the effect of commonly used topical antibiotics on the bacteria that live in the nose, throat and on the skin of older adults. In addition, the investigators want to determine if these topical antibiotics affect how bacteria are spread in Community Living Centers of the VA Maryland Health Care System.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 50 years or older.
- •Living in a participating nursing home for at least 80% of the past 3 months-
- •Willing to provide anterior nares, posterior pharynx, skin and throat specimens over the study period.
- •Willing to use intranasal mupirocin and topical chlorhexidine over a five day period.
- •Provide signed and dated informed consent from subject or LAR.
排除标准
- •Recent history of MRSA colonization
- •Use of mupirocin nasal ointment in past 3 months
- •Use of topical chlorhexidine in past 3 months
- •History of an allergic reaction to chlorhexidine or mupirocin
研究组 & 干预措施
Intranasal Mupirocin and Topical Chlorhexidine
干预措施: Intranasal Mupirocin and Topical Chlorhexidine (Drug)
结局指标
主要结局
Change in the Abundance of Staphylococcus Aureus in the Nose After Decolonization
时间窗: 8 weeks
Change in the abundance of Staphylococcus aureus in the nose from immediately before mupirocin administration to 8 weeks after mupirocin administration.
Change in the Abundance of Gram Negative Bacteria on the Subclavian Skin After Decolonization
时间窗: 12 months
Quantitative PCR using 16s rRNA is used to quantify the total bacterial load of Gram negative bacteria on the subclavian skin before and after decolonization.
Change in the Abundance of Staphylococcus Aureus in the Throat After Decolonization
时间窗: 8 weeks
Change in the abundance of Staphylococcus aureus in the throat from immediately before mupirocin administration to 8 weeks after mupirocin administration.
Change in the Abundance of Gram Negative Bacteria on the Femoral Skin After Decolonization
时间窗: 12 months
Quantitative PCR using 16s rRNA is used to quantify the total bacterial load of Gram negative bacteria on the femoral skin before and after decolonization.
次要结局
未报告次要终点
研究者
Mary-Claire Roghmann
Professor
University of Maryland, Baltimore