Does Asthma Phenotype Have Impact on Disease Control

Completed

• Conditions: Asthma
• Interventions: Drug: Pulmicort

• Registration Number: NCT01978678
• Lead Sponsor: Bispebjerg Hospital

Brief Summary

The application of biomarkers that are more closely associated with eosinophillic airway inflammation, such as measurements of FeNO level, cell count in induced sputum or bronchial reactivity could improve asthma control by better directing treatment. A systematic review and meta-analysis is to be conducted to assess the efficacy of tailoring asthma intervention on clinical symptoms compared with exhaled nitric oxide or induced sputum count.

Detailed Description

AHR used as outcome

Study Timeline

• Study Start: 2012-11
• Status Verified: 2013-11
• Study First Submitted: 2013-11-01
• Study First Submitted QC: 2013-11-06
• Study First Posted: 2013-11-07
• Primary Completion: 2015-01
• Study Completion: 2015-01
• Last Update Submitted: 2020-01-31
• Last Update Posted: 2020-02-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• positiv mannitol
• asthma diagnose

Exclusion Criteria

• other lung disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Pulmicort	Pulmicort	ICS and LABA - based on ACQ and FeNO

Primary Outcome Measures

Name	Time	Method
Control of asthma based on an algorithm	2 years	Based on ACQ and FeNO

Secondary Outcome Measures

Name	Time	Method
The use of NO and sputum cell count as a marker in asthma management	2 years	Based on ACQ and FeNO

Trial Locations

Locations (2)

Respiratory research unit, Bispebjerg University Hospital; 🇩🇰 Copenhagen, Denmark

Department of Respiratory Medicine, L, Bispebjerg Hospital,; 🇩🇰 Copenhagen, NV, Denmark