High Serum Ferritin Early in Pregnancy May Predict the Development of Gestational Diabetes Later.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 556
- 试验地点
- 1
- 主要终点
- Success Rate of Diagnostic Regimens in Predicting Gestational Diabetes Mellitus
研究概览
简要总结
This prospective study evaluates a target population of pregnant women at the time of pregnancy diagnosis to investigate the predictive value of serum ferritin (SF) levels for the later development of gestational diabetes mellitus (GDM). The intervention involves measuring early-pregnancy SF, transferrin, and hemoglobin levels, alongside HbA1c, and comparing these biomarkers between women who later develop GDM and those who remain normoglycemic. The primary outcome is to assess the success rate of this diagnostic regimen in identifying high-risk individuals, aiming to establish SF as a valuable early biomarker for GDM to enable timely interventions.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 21 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Confirmed pregnancy at an early gestational age.
- •Provision of clinical and family history (e.g., age, BMI, history of GDM).
排除标准
- •Pre-existing Type 1 or Type 2 Diabetes Mellitus.
- •Conditions known to significantly alter iron metabolism independent of pregnancy.
研究组 & 干预措施
GDM Group
Pregnant women who develop gestational diabetes mellitus later in pregnancy.
干预措施: Glycemic Markers (Diagnostic Test)
Non GDM Group
Pregnant women who maintain normal glucose tolerance throughout pregnancy.
干预措施: Glycemic Markers (Diagnostic Test)
结局指标
主要结局
Success Rate of Diagnostic Regimens in Predicting Gestational Diabetes Mellitus
时间窗: 24-28 weeks gestation
The efficacy of early pregnancy Serum Ferritin (SF) levels in accurately identifying women who will subsequently meet the diagnostic criteria for GDM.
次要结局
- Iron Homeostasis Markers(24-28 weeks gestation)
研究者
Bassem Mohamed Talaat Abdelaziz Ali
Assistant Professor of Obestitrics and gynecology
Zagazig University