Adrenal insufficiency in children with cancer after chemotherapy
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Proportion of children with adrenal insufficiency after low dose ACTH stimulation test
研究概览
简要总结
Chemotherapy-related transient Hypothalamo-Pituitary-Adrenal Axis dysfunction is reported during acute periods of treatment in childhood cancers, but evidence of its permanence is less known. In earlier study in children with cancer reported low serum cortisol in 52% of patients during acute febrile illness. Few studies have reported partial recovery of adrenal function after induction therapy of cancer treatment over a variable period of time. However, evidence of adrenal insufficiency after the acute period and the need for stress dosing of steroids on follow-up is lacking. Hence, we plan to estimate the proportion of children with adrenal insufficiency after chemotherapy for cancer.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 6.00 Month(s) 至 12.00 Year(s)（—）
- 性别
- All
入选标准
- •Who Have received chemotherapy for childhood cancer for a minimum of three month period in last two years.
排除标准
- •History of systemic steroid intake in last 3 months, any previous known endocrine disorders, septic shock, febrile neutropenia, critically ill child.
结局指标
主要结局
Proportion of children with adrenal insufficiency after low dose ACTH stimulation test
时间窗: baseline, 60 mins
次要结局
- Proportion of children with low thyroid stimulating hormone and/or low free thyroxine(baseline)
研究者
Dr Ankita Soni
Maulana Azad Medical College